John H Leamon
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Explore the profile of John H Leamon including associated specialties, affiliations and a list of published articles.
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10
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4320
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Recent Articles
1.
Sabina J, Leamon J
Methods Mol Biol
. 2015 Sep;
1347:15-41.
PMID: 26374307
Whole genome amplification (WGA) is a widely used molecular technique that is becoming increasingly necessary in genetic research on a range of sample types including individual cells, fossilized remains and...
2.
Rothberg J, Hinz W, Rearick T, Schultz J, Mileski W, Davey M, et al.
Nature
. 2011 Jul;
475(7356):348-52.
PMID: 21776081
The seminal importance of DNA sequencing to the life sciences, biotechnology and medicine has driven the search for more scalable and lower-cost solutions. Here we describe a DNA sequencing technology...
3.
Kiss M, Ortoleva-Donnelly L, Beer N, Warner J, Bailey C, Colston B, et al.
Anal Chem
. 2009 Jun;
80(23):8975-81.
PMID: 19551929
Limiting dilution PCR has become an increasingly useful technique for the detection and quantification of rare species in a population, but the limit of detection and accuracy of quantification are...
4.
Rothberg J, Leamon J
Nat Biotechnol
. 2008 Oct;
26(10):1117-24.
PMID: 18846085
The 454 Sequencer has dramatically increased the volume of sequencing conducted by the scientific community and expanded the range of problems that can be addressed by the direct readouts of...
5.
6.
Pinard R, de Winter A, Sarkis G, Gerstein M, Tartaro K, Plant R, et al.
BMC Genomics
. 2006 Aug;
7:216.
PMID: 16928277
Background: Whole genome amplification is an increasingly common technique through which minute amounts of DNA can be multiplied to generate quantities suitable for genetic testing and analysis. Questions of amplification-induced...
7.
Leamon J, Link D, Egholm M, Rothberg J
Nat Methods
. 2006 Jun;
3(7):541-3.
PMID: 16791212
Three protocols in this issue highlight applications of emulsification procedures, which deliver high-throughput potential to the molecular biology laboratory, without the need for automation. These procedures have already generated interesting...
8.
Margulies M, Egholm M, Altman W, Attiya S, Bader J, Bemben L, et al.
Nature
. 2005 Aug;
437(7057):376-80.
PMID: 16056220
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system...
9.
Leamon J, Lee W, Tartaro K, Lanza J, Sarkis G, deWinter A, et al.
Electrophoresis
. 2003 Nov;
24(21):3769-77.
PMID: 14613204
We demonstrate successful, simultaneous polymerase chain reaction (PCR) amplification of up to 300 000 discrete reactions in a novel platform, the PicoTiterPlate. In addition to elevated throughput, the PicoTiterPlate based...
10.
Lage J, Leamon J, Pejovic T, Hamann S, Lacey M, Dillon D, et al.
Genome Res
. 2003 Feb;
13(2):294-307.
PMID: 12566408
Structural genetic alterations in cancer often involve gene loss or gene amplification. With the advent of microarray approaches for the analysis of the genome, as exemplified by array-CGH (Comparative Genomic...