John F Langenheim
Overview
Explore the profile of John F Langenheim including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
243
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0
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Recent Articles
1.
Simmons R, Kameyama H, Kubota S, Sun Y, Langenheim J, Ajeeb R, et al.
Breast Cancer Res Treat
. 2024 Jul;
208(1):165-177.
PMID: 38969944
Purpose: We have previously reported that protracted Cyclooxygenase-2 (COX-2) activity in bone marrow-derived cells (BMDCs) infiltrating into biopsy wounds adjacent to the biopsy cavity of breast tumors in mice promotes...
2.
Kameyama H, Dondapati P, Simmons R, Leslie M, Langenheim J, Sun Y, et al.
Cell Rep Med
. 2023 Dec;
4(12):101330.
PMID: 38118415
Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage...
3.
Chervoneva I, Peck A, Sun Y, Yi M, Udhane S, Langenheim J, et al.
JCO Precis Oncol
. 2023 Jan;
7:e2100498.
PMID: 36652667
Purpose: T-cell-mediated cytotoxicity is suppressed when programmed cell death-1 (PD-1) is bound by PD-1 ligand-1 (PD-L1) or PD-L2. Although PD-1 inhibitors have been approved for triple-negative breast cancer, the lower...
4.
McFall T, Trogdon M, Guizar A, Langenheim J, Sisk-Hackworth L, Stites E
NPJ Precis Oncol
. 2022 Nov;
6(1):86.
PMID: 36418474
The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and...
5.
Sun Y, Yang N, Utama F, Udhane S, Zhang J, Peck A, et al.
Sci Adv
. 2021 Sep;
7(38):eabc8145.
PMID: 34524841
Most breast cancer deaths are caused by estrogen receptor-α–positive (ER) disease. Preclinical progress is hampered by a shortage of therapy-naïve ER tumor models that recapitulate metastatic progression and clinically relevant...
6.
Sun Y, Ge L, Udhane S, Langenheim J, Rau M, Patton M, et al.
Methods Protoc
. 2021 Jul;
4(3).
PMID: 34287344
Human coronavirus disease 2019 (COVID-19) is a life-threatening and highly contagious disease caused by coronavirus SARS-CoV-2. Sensitive and specific detection of SARS-CoV-2 viral proteins in tissues and cells of COVID-19...
7.
Felix J, Sheinin Y, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, et al.
Ann Diagn Pathol
. 2021 May;
53:151744.
PMID: 33991784
Objectives: Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness. Methods: Lungs of 12 consecutive...
8.
Tran T, Utama F, Sato T, Peck A, Langenheim J, Udhane S, et al.
Clin Cancer Res
. 2018 Aug;
24(24):6355-6366.
PMID: 30097435
Purpose: Parathyroid hormone-related protein (PTHrP) is required for normal mammary gland development and biology. A gene polymorphism is associated with breast cancer risk, and PTHrP promotes growth of osteolytic breast...
9.
Liu Y, Zhang Y, Jiang J, Lobie P, Paulmurugan R, Langenheim J, et al.
Mol Endocrinol
. 2016 Mar;
30(5):504-17.
PMID: 27003442
GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane cytokine receptors. Each prehomodimerizes and ligand binding activates Janus Kinase 2 (JAK2)-signal transducer and activator of transcription (STAT) signaling...
10.
Kim B, Yoo J, Kim T, Shin J, Langenheim J, Ferguson S, et al.
Hum Reprod
. 2015 Mar;
30(5):1069-78.
PMID: 25750101
Study Question: Are STAT3 signaling molecules differentially expressed in endometriosis? Summary Answer: Levels of phospho-STAT3 and HIF1A, its downstream signaling molecule, are significantly higher in eutopic endometrium from women with...