John F Kearney
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Explore the profile of John F Kearney including associated specialties, affiliations and a list of published articles.
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75
Citations
2704
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Recent Articles
1.
New J, Fucile C, Callahan A, Burke J, Davis R, Duck W, et al.
bioRxiv
. 2024 Oct;
PMID: 39464096
The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the universe of all living things, including both the host/self- as well as the commensal microflora-derived glycomes. Here...
2.
Peel J, Owiredu E, Rosenberg A, Silva-Sanchez A, Randall T, Kearney J, et al.
J Immunol
. 2024 Oct;
213(12):1771-1786.
PMID: 39451043
The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn/J [µMT]...
3.
Stewart New J, Glenn King R, Foote J, Kearney J
Curr Opin Immunol
. 2024 Aug;
89:102452.
PMID: 39180941
Microbiota-derived antigens play a critical role in the development of both the mucosal and systemic B cell repertoires; however, how glycan epitopes promote B cell repertoire selection is only recently...
4.
New J, Dizon B, Kearney J, King R
J Immunol
. 2024 Apr;
212(12):1913-1921.
PMID: 38647373
Using an Ig H chain conferring specificity for N-acetyl-d-glucosamine (GlcNAc), we developed transgenic (VHHGAC39 TG) mice to study the role of self-antigens in GlcNAc-reactive B-1 B cell development. In VHHGAC39...
5.
New J, Dizon B, King R, Greenspan N, Kearney J
J Immunol
. 2023 Sep;
211(9):1320-1331.
PMID: 37747293
Environmental factors and host microbiota strongly influence type 1 diabetes (T1D) progression. We report that neonatal immunization with group A Streptococcus suppresses T1D development in NOD mice by promoting clonal...
6.
Chattopadhyay D, Walker D, Rich-New S, Kearney J, Turnbough Jr C
mBio
. 2023 Jun;
14(4):e0117223.
PMID: 37382447
The outermost exosporium layer of spores, the causative agents of anthrax, is comprised of a basal layer and an external hair-like nap. The nap includes filaments composed of trimers of...
7.
Killian J, King R, Lucander A, Kizziah J, Fucile C, Diaz-Avalos R, et al.
bioRxiv
. 2023 Apr;
PMID: 37034637
Donor-specific antibody (DSA) responses against human leukocyte antigen (HLA) proteins mismatched between kidney transplant donors and recipients cause allograft loss. The rules governing the immunogenicity of non-self donor HLA are...
8.
Barington L, Christensen L, Pedersen K, Niss Arfelt K, Roumain M, Jensen K, et al.
Cells
. 2022 Feb;
11(3).
PMID: 35159303
B1 cells constitute a specialized subset of B cells, best characterized in mice, which is abundant in body cavities, including the peritoneal cavity. Through natural and antigen-induced antibody production, B1...
9.
Cordero H, King R, Dogra P, Dufeu C, See S, Chong A, et al.
Nat Commun
. 2021 Oct;
12(1):5761.
PMID: 34599177
The thymus is a central lymphoid organ primarily responsible for the development of T cells. A small proportion of B cells, however, also reside in the thymus to assist negative...
10.
New J, Dizon B, Fucile C, Rosenberg A, Kearney J, King R
Immunity
. 2020 Jul;
53(1):172-186.e6.
PMID: 32610078
B-1 B cells derive from a developmental program distinct from that of conventional B cells, through B cell receptor (BCR)-dependent positive selection of fetally derived precursors. Here, we used direct...