John F Brothers 2nd
Overview
Explore the profile of John F Brothers 2nd including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
158
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0
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Recent Articles
1.
Brothers 2nd J, Ung M, Escalante-Chong R, Ross J, Zhang J, Cha Y, et al.
Biochem Pharmacol
. 2018 Mar;
152:84-93.
PMID: 29551586
The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug discovery and development. In the field of life sciences, the growth...
2.
Suzuki M, Sze M, Campbell J, Brothers 2nd J, Lenburg M, McDonough J, et al.
Sci Rep
. 2017 Aug;
7(1):9562.
PMID: 28842670
The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before the onset of emphysematous destruction in COPD. This report extends those...
3.
Kusko R, Brothers 2nd J, Tedrow J, Pandit K, Huleihel L, Perdomo C, et al.
Am J Respir Crit Care Med
. 2016 Apr;
194(8):948-960.
PMID: 27104832
Rationale: Despite shared environmental exposures, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease are usually studied in isolation, and the presence of shared molecular mechanisms is unknown. Objectives: We...
4.
Wang X, Pittman G, Bandele O, Bischof J, Liu G, Brothers 2nd J, et al.
Hum Genet
. 2014 Sep;
133(12):1467-76.
PMID: 25179167
Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury in the airway and altering gene expression. Studies of...
5.
Krysan K, Cui X, Gardner B, Reckamp K, Wang X, Hong L, et al.
Am J Transl Res
. 2013 Aug;
5(5):481-96.
PMID: 23977408
Purpose: The EGFR tyrosine kinase inhibitors (TKIs) demonstrate efficacy in NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who initially respond to EGFR TKI treatment invariably develop resistance...
6.
Gower A, Steiling K, Brothers 2nd J, Lenburg M, Spira A
Proc Am Thorac Soc
. 2011 May;
8(2):173-9.
PMID: 21543797
The "field of injury" hypothesis proposes that exposure to an inhaled insult such as cigarette smoke elicits a common molecular response throughout the respiratory tract. This response can therefore be...