John F Bower
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Explore the profile of John F Bower including associated specialties, affiliations and a list of published articles.
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93
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1219
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Recent Articles
1.
Mao W, Robertson C, Bower J
J Am Chem Soc
. 2024 Dec;
147(1):118-124.
PMID: 39715233
Under iridium-catalyzed conditions, 2-aza-aryl-substituted secondary alcohols undergo C(sp)-H addition reactions to alkynes to provide alkenylated tertiary alcohols. The processes occur with very high regio- and enantioselectivity. An analogous addition to...
2.
Figueroa L, de Carvalho R, Almeida R, Paz E, Diogo E, Araujo M, et al.
RSC Med Chem
. 2024 Nov;
PMID: 39512946
The regioselective synthesis of functionalized naphthoquinones the formation and capture of naphthoquinonynes has been used to prepare trypanocidal compounds. The target compounds are functionalized on the aromatic ring, leaving the...
3.
Ledwith P, Cooney M, Bahou K, Garcia-Carceles J, Thomson J, Bower J
Angew Chem Int Ed Engl
. 2024 Sep;
63(50):e202411555.
PMID: 39219402
We report a strategy for the formal C-N cross-coupling of tertiary amines via the in situ generation and displacement of N-acyl ammonium species. Specifically, treatment of diverse tertiary amines with...
4.
Tu W, Farndon J, Robertson C, Bower J
Angew Chem Int Ed Engl
. 2024 Aug;
63(49):e202409836.
PMID: 39171407
Under acidic conditions (TFA) and in the presence of water, BocNHOTs promotes stereospecific 1,2-aminohydroxylations of alkenes. The processes involve intermolecular aza-Prilezhaev aziridination followed by stereospecific S2 opening by water. This...
5.
Hong F, Robertson C, Bower J
J Am Chem Soc
. 2024 Aug;
146(33):22923-22929.
PMID: 39106062
Cationic Ir(I)-complexes modified with homochiral diphosphines promote the hydroalkenylative cross-coupling of β-(arylamino)acrylates with monosubstituted styrenes and α-olefins. The processes are dependent on the presence of an NH unit, and it...
6.
Hong F, Aldhous T, Kemmitt P, Bower J
Nat Chem
. 2024 Apr;
16(7):1125-1132.
PMID: 38565976
Homochiral α-amino acids are widely used in pharmaceutical design as key subunits in chiral catalyst synthesis or as building blocks in synthetic biology. Many synthetic methods have been developed to...
7.
de Carvalho R, Wood J, Almeida R, Berry N, da Silva Junior E, Bower J
Angew Chem Int Ed Engl
. 2024 Mar;
63(18):e202400188.
PMID: 38445547
The first systematic exploration of the synthesis and reactivity of naphthoquinonynes is described. Routes to two regioisomeric Kobayashi-type naphthoquinonyne precursors have been developed, and the reactivity of the ensuing 6,7-...
8.
Jing C, Mao W, Bower J
J Am Chem Soc
. 2023 Oct;
145(44):23918-23924.
PMID: 37879082
Upon exposure to a cationic Ir(I)-complex modified with the chiral diphosphine DuanPhos, hydroalkylations of styrenes and α-olefins with diverse heteroaryl -butyl acetates occur with complete branched selectivity and very high...
9.
Smith M, Tu W, Robertson C, Bower J
Angew Chem Int Ed Engl
. 2023 Oct;
62(48):e202312797.
PMID: 37846756
Under acidic reaction conditions (TFA), deprotection of BocNR(OSO R) reagents triggers intermolecular aminative cyclizations of alkenes equipped with pendant nucleophiles. The processes are predicated on a sequence of stereospecific intermolecular...
10.
Scott S, Cadge J, Boden G, Bower J, Russell C
Angew Chem Int Ed Engl
. 2023 Mar;
62(23):e202301526.
PMID: 36995930
We describe a Au complex of a hemi-labile (C^N) N-heterocyclic carbene ligand that is able to mediate oxidative addition of aryl iodides. Detailed computational and experimental investigations have been undertaken...