John F Andersen
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Explore the profile of John F Andersen including associated specialties, affiliations and a list of published articles.
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90
Citations
3267
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Recent Articles
1.
Martins L, Berger M, Kotal J, Lu S, Sousa-Paula L, Smith B, et al.
Int J Biol Macromol
. 2024 Nov;
284(Pt 1):137949.
PMID: 39579814
Ticks obtain a blood meal by lacerating small blood vessels and ingesting the blood that flows to the feeding site, which triggers various host responses. However, ticks face the challenge...
2.
Andersen J, Lei H, Strayer E, Pham V, Ribeiro J
Commun Biol
. 2024 May;
7(1):649.
PMID: 38802531
Salivary complement inhibitors occur in many of the blood feeding arthropod species responsible for transmission of pathogens. During feeding, these inhibitors prevent the production of proinflammatory anaphylatoxins, which may interfere...
3.
Alvarenga P, Alves E Silva T, Suzuki M, Nardone G, Cecilio P, Vega-Rodriguez J, et al.
J Proteome Res
. 2024 Apr;
23(4):1471-1487.
PMID: 38576391
In arthropods, hemolymph carries immune cells and solubilizes and transports nutrients, hormones, and other molecules that are involved in diverse physiological processes including immunity, metabolism, and reproduction. However, despite such...
4.
Lu S, Andersen J, Bosio C, Hinnebusch B, Ribeiro J
Commun Biol
. 2023 Dec;
6(1):1280.
PMID: 38110569
The salivary glands of hematophagous arthropods contain pharmacologically active molecules that interfere with host hemostasis and immune responses, favoring blood acquisition and pathogen transmission. Exploration of the salivary gland composition...
5.
Andersen J, Lei H, Strayer E, Kanai T, Pham V, Pan X, et al.
Blood
. 2023 Mar;
141(25):3109-3121.
PMID: 36947859
Inhibitors of complement and coagulation are present in the saliva of a variety of blood-feeding arthropods that transmit parasitic and viral pathogens. Here, we describe the structure and mechanism of...
6.
Alvarenga P, Andersen J
Biology (Basel)
. 2023 Jan;
12(1).
PMID: 36671732
Each time an insect bites a vertebrate host, skin and vascular injury caused by piercing triggers a series of responses including hemostasis, inflammation and immunity. In place, this set of...
7.
Lee S, Low L, Andersen J, Yeoh L, Valenzuela Leon P, Drew D, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2215003120.
PMID: 36577076
We used a transgenic parasite in which parasites were genetically modified to express apical membrane antigen 1 (PvAMA1) protein in place of PfAMA1 to study PvAMA1-mediated invasion. In , AMA1...
8.
Mans B, Andersen J, Ribeiro J
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555254
Hard ticks feed for several days or weeks on their hosts and their saliva contains thousands of polypeptides belonging to dozens of families, as identified by salivary transcriptomes. Comparison of...
9.
Alvarenga P, Dias D, Xu X, Francischetti I, Gittis A, Arp G, et al.
Insect Biochem Mol Biol
. 2022 May;
146:103785.
PMID: 35568118
The D7 proteins are highly expressed in the saliva of hematophagous Nematocera and bind biogenic amines and eicosanoid compounds produced by the host during blood feeding. These proteins are encoded...
10.
Lu S, Andersen J, Bosio C, Hinnebusch B, Ribeiro J
J Proteomics
. 2022 Jan;
254:104476.
PMID: 34990822
Over the last 20 years, advances in sequencing technologies paired with biochemical and structural studies have shed light on the unique pharmacological arsenal produced by the salivary glands of hematophagous...