John E Harrison
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Explore the profile of John E Harrison including associated specialties, affiliations and a list of published articles.
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26
Citations
585
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Recent Articles
1.
van den Berg R, de Boer C, Zwan M, Jutten R, van Liere M, van de Glind M, et al.
Alzheimers Res Ther
. 2024 Aug;
16(1):176.
PMID: 39090738
Background: Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer's disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) pathology of...
2.
Dubbelman M, Hendriksen H, Harrison J, Vijverberg E, Prins N, Kroeze L, et al.
Neurology
. 2024 Jan;
102(2):e207978.
PMID: 38165338
Background And Objectives: It is unclear to what extent cognitive outcome measures are sensitive to capture decline in Alzheimer disease (AD) prevention trials. We aimed to analyze the sensitivity to...
3.
Dubbelman M, Postema M, Jutten R, Harrison J, Ritchie C, Aleman A, et al.
Neuropsychology
. 2023 Sep;
38(1):96-105.
PMID: 37676135
Objective: We aimed to investigate whether item response theory (IRT)-based scoring allows for a more accurate, responsive, and less biased assessment of everyday functioning than traditional classical test theory (CTT)-based...
4.
Jiang Y, Alam J, Gomperts S, Maruff P, Lemstra A, Germann U, et al.
Nat Commun
. 2022 Sep;
13(1):5308.
PMID: 36130946
The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α is...
5.
Dalby M, Annas P, Harrison J
Int J Methods Psychiatr Res
. 2022 Jun;
31(4):e1922.
PMID: 35748111
Introduction: We report further validation and normative data for the THINC-Integrated Tool (THINC-it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which...
6.
Myers J, Glenn J, Madero E, Anderson J, Mak-McCully R, Gray M, et al.
JMIR Form Res
. 2022 Feb;
6(2):e34237.
PMID: 35179511
Background: As evidenced by the further reduction in access to testing during the COVID-19 pandemic, there is an urgent, growing need for remote cognitive assessment for individuals with cognitive impairment....
7.
Prins N, Harrison J, Chu H, Blackburn K, Alam J, Scheltens P
Alzheimers Res Ther
. 2021 May;
13(1):106.
PMID: 34044875
Background: In preclinical studies, p38⍺ kinase is implicated in Alzheimer's disease (AD) pathogenesis. In animal models, it mediates impaired synaptic dysfunction in the hippocampus, causing memory deficits, and is involved...
8.
Harrison J
Alzheimers Dement (Amst)
. 2021 Feb;
12(1):e12009.
PMID: 33521231
In this commentary I consider the issues raised in Schneider and Goldberg's review of composite cognitive and functional measures. I find much to agree with in their commentary and especially...
9.
Robin J, Harrison J, Kaufman L, Rudzicz F, Simpson W, Yancheva M
Digit Biomark
. 2020 Nov;
4(3):99-108.
PMID: 33251474
Speech represents a promising novel biomarker by providing a window into brain health, as shown by its disruption in various neurological and psychiatric diseases. As with many novel digital biomarkers,...
10.
Jutten R, Harrison J, Brunner A, Vreeswijk R, van Deelen R, de Jong F, et al.
Alzheimers Dement (N Y)
. 2020 Apr;
6(1):e12020.
PMID: 32313832
Introduction: In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive-Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional...