John E Cronan
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Explore the profile of John E Cronan including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Cronan J
Mol Microbiol
. 2023 May;
119(6):687-694.
PMID: 37140060
Coenzyme A (CoA) is an essential cofactor throughout biology. The first committed step in the CoA synthetic pathway is synthesis of β-alanine from aspartate. In Escherichia coli and Salmonella enterica...
12.
Dong H, Wang H, Cronan J
Mol Microbiol
. 2022 Dec;
119(2):252-261.
PMID: 36537550
The genomes of the best-studied pseudomonads, Pseudomonas aeruginosa and Pseudomonas putida, which share 85% of the predicted coding regions, contain a fabA fabB operon (demonstrated in P. aeruginosa, putative in...
13.
Dong H, Cronan J
Mol Microbiol
. 2022 Sep;
118(5):541-551.
PMID: 36100979
The Enterococcus faecalis genome contains two enoyl-ACP reductases genes, fabK and fabI, which encode proteins having very different structures. Enoyl-ACP reductase catalyzes the last step of the elongation cycle of...
14.
Dong H, Cronan J
J Bacteriol
. 2022 Aug;
204(9):e0020222.
PMID: 35920666
Enterococcus faecalis encodes two proteins, AcpA and AcpB, having the characteristics of acyl carrier proteins (ACPs). We report that the gene located in the fatty acid synthesis operon is essential...
15.
Zou Q, Dong H, Zhu L, Cronan J
Front Microbiol
. 2022 May;
13:877582.
PMID: 35547134
The phospholipid acyl chains of can be derived either by synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway. Exogenous fatty...
16.
Cronan J, Luk T
Microbiol Mol Biol Rev
. 2022 Apr;
86(2):e0001322.
PMID: 35435731
Cyclopropane fatty acid (CFA) synthase catalyzes a remarkable reaction. The double bonds of unsaturated fatty acyl chains of phospholipid bilayers are converted to cyclopropane rings by transfer of a methylene...
17.
Zhou J, Zhang L, Zeng L, Yu L, Duan Y, Shen S, et al.
Nat Commun
. 2021 Nov;
12(1):6932.
PMID: 34836944
Unsaturated fatty acids (UFAs) are essential for functional membrane phospholipids in most bacteria. The bifunctional dehydrogenase/isomerase FabX is an essential UFA biosynthesis enzyme in the widespread human pathogen Helicobacter pylori,...
18.
Song X, Cronan J
Mol Microbiol
. 2021 Oct;
116(5):1315-1327.
PMID: 34597430
Biotin is an essential metabolic cofactor and de novo biotin biosynthetic pathways are widespread in microorganisms and plants. Biotin synthetic genes are generally found clustered into bio operons to facilitate...
19.
Dong H, Ma J, Chen Q, Chen B, Liang L, Liao Y, et al.
J Biol Chem
. 2021 Jun;
297(2):100920.
PMID: 34181948
The Pseudomonas putida F1 genome contains five genes annotated as encoding 3-ketoacyl-acyl carrier protein (ACP) synthases. Four are annotated as encoding FabF (3-ketoacyl-ACP synthase II) proteins, and the fifth is...
20.
Cronan J
Microbiol Mol Biol Rev
. 2021 Jun;
85(3):e0003221.
PMID: 34132100
Escherichia coli acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of malonyl-CoA, the building block of fatty acid synthesis, is the paradigm bacterial ACC. Many reports on the structures and...