John D Elsworth
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Explore the profile of John D Elsworth including associated specialties, affiliations and a list of published articles.
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63
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2000
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Recent Articles
11.
Blackburn J, Curry D, Thomsen A, Roth R, Elsworth J
Exp Neurol
. 2020 Feb;
327:113234.
PMID: 32044330
Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the...
12.
De Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond Jr D
Methods Mol Biol
. 2019 Jun;
2005:221-231.
PMID: 31175656
The search for a better animal model to simulate human disease has been a "holy grail" of biomedical research for decades. Recent identification of different types of pluripotent stem cells...
13.
Stutz B, Nasrallah C, Nigro M, Curry D, Liu Z, Gao X, et al.
Mol Metab
. 2019 Mar;
24:120-138.
PMID: 30833218
Objective: Dopamine neurons in the Substantia nigra (SN) play crucial roles in control of voluntary movement. Extensive degeneration of this neuronal population is the cause of Parkinson's disease (PD). Many...
14.
De Los Angeles A, Elsworth J, Redmond Jr D
Biochem Biophys Res Commun
. 2019 Jan;
510(1):78-84.
PMID: 30660369
Generating human organs inside interspecies chimeras might one day produce patient-specific organs for clinical applications, but further advances in identifying human chimera-competent pluripotent stem (PS) cells are needed. Moreover, the...
15.
De Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond Jr D
Stem Cells Dev
. 2018 Oct;
27(23):1599-1604.
PMID: 30319057
The search for a better animal model to simulate human disease has been a "holy grail" of biomedical research for decades. Recent identification of different types of pluripotent stem (PS)...
16.
Curry D, Stutz B, Andrews Z, Elsworth J
J Parkinsons Dis
. 2018 Apr;
8(2):161-181.
PMID: 29614701
Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterized by the accumulation of intracellular α-synuclein aggregates and the degeneration of nigrostriatal dopaminergic neurons. While no treatment...
17.
Sousa A, Zhu Y, Raghanti M, Kitchen R, Onorati M, Tebbenkamp A, et al.
Science
. 2017 Nov;
358(6366):1027-1032.
PMID: 29170230
To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains....
18.
Golub M, Hackett E, Hogrefe C, Leranth C, Elsworth J, Roth R
Dev Cogn Neurosci
. 2017 May;
26:52-61.
PMID: 28521247
Potential long term effects on brain development are a concern when drugs are used to treat depression and anxiety in childhood. In this study, male juvenile rhesus monkeys (three-four years...
19.
Bayliss J, Lemus M, Santos V, Deo M, Davies J, Kemp B, et al.
PLoS One
. 2016 Jul;
11(7):e0159381.
PMID: 27467571
Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies show it has wide ranging effects to treat other diseases. Animal and retrospective human studies indicate...
20.
Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, et al.
Cell Transplant
. 2016 May;
25(11):1945-1966.
PMID: 27213850
Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical...