John C Trefry
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Explore the profile of John C Trefry including associated specialties, affiliations and a list of published articles.
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19
Citations
717
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Recent Articles
1.
Honko A, Hunegnaw R, Moliva J, Ploquin A, Dulan C, Murray T, et al.
bioRxiv
. 2024 Feb;
PMID: 38410448
Infection with Sudan virus (SUDV) is characterized by an aggressive disease course with case fatality rates between 40-100% and no approved vaccines or therapeutics. SUDV causes sporadic outbreaks in sub-Saharan...
2.
Williams J, Long S, Zeng X, Kuehl K, Babka A, Davis N, et al.
PLoS Negl Trop Dis
. 2022 May;
16(5):e0010081.
PMID: 35533188
Eastern equine encephalitis virus (EEEV) is mosquito-borne virus that produces fatal encephalitis in humans. We recently conducted a first of its kind study to investigate EEEV clinical disease course following...
3.
Liu J, Trefry J, Babka A, Schellhase C, Coffin K, Williams J, et al.
Sci Transl Med
. 2022 Feb;
14(631):eabi5229.
PMID: 35138912
Effective therapeutics have been developed against acute Ebola virus disease (EVD) in both humans and experimentally infected nonhuman primates. However, the risk of viral persistence and associated disease recrudescence in...
4.
Trefry J, Rossi F, Accardi M, Dorsey B, Sprague T, Wollen-Roberts S, et al.
PLoS Negl Trop Dis
. 2021 Jun;
15(6):e0009424.
PMID: 34138849
Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality...
5.
Downs I, Shaia C, Zeng X, Johnson J, Hensley L, Saunders D, et al.
Viruses
. 2020 Jun;
12(6).
PMID: 32485952
Lassa virus (LASV), an arenavirus causing Lassa fever, is endemic to West Africa with up to 300,000 cases and between 5000 and 10,000 deaths per year. Rarely seen in the...
6.
Reisler R, Zeng X, Schellhase C, Bearss J, Warren T, Trefry J, et al.
Viruses
. 2018 Sep;
10(10).
PMID: 30241284
In the 2014⁻2016 West Africa Ebola Virus (EBOV) outbreak, there was a significant concern raised about the potential for secondary bacterial infection originating from the gastrointestinal tract, which led to...
7.
Sanchez-Lockhart M, Reyes D, Gonzalez J, Garcia K, Villa E, Pfeffer B, et al.
Cell Rep
. 2018 Jul;
24(4):1050-1059.e5.
PMID: 30044972
Development of an effective vaccine became a worldwide priority after the devastating 2013-2016 Ebola disease outbreak. To qualitatively profile the humoral response against advanced filovirus vaccine candidates, we developed Domain...
8.
Pascal K, Dudgeon D, Trefry J, Anantpadma M, Sakurai Y, Murin C, et al.
J Infect Dis
. 2018 Jun;
218(suppl_5):S612-S626.
PMID: 29860496
Background: For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic...
9.
Haddow A, Nasar F, Schellhase C, Moon R, Padilla S, Zeng X, et al.
Parasit Vectors
. 2017 May;
10(1):218.
PMID: 28468673
Background: Ebola virus (EBOV) infection results in high morbidity and mortality and is primarily transmitted in communities by contact with infectious bodily fluids. While clinical and experimental evidence indicates that...
10.
Corti D, Misasi J, Mulangu S, Stanley D, Kanekiyo M, Wollen S, et al.
Science
. 2016 Feb;
351(6279):1339-42.
PMID: 26917593
Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need...