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John C Morrison

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Articles 210
Citations 3875
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Recent Articles
1.
Morrison J, Cepurna W, Ing E, Johnson E, Abtin A, Wentzien S, et al.
Exp Eye Res . 2025 Jan; 251:110237. PMID: 39805385
Animal models that help us understand how elevated intraocular pressure (IOP) causes axonal injury will lead to new glaucoma therapies. Because reliable measurements are difficult to obtain in chronic models,...
2.
Liang G, Ni S, Hormel T, Morrison J, Lozano D, Jian Y, et al.
Opt Lett . 2024 Nov; 49(22):6449-6452. PMID: 39546690
This study introduces an ultra-wide field (UWF) and high-resolution swept-source optical coherence tomographic angiography (OCTA) system for rat retinal imaging. Using an asymmetrical optics design, the system achieves unprecedented details...
3.
Lozano D, Johnson E, Cepurna W, Morrison J
Methods Mol Biol . 2024 Oct; 2858:229-241. PMID: 39433680
Experimental elevation of intraocular pressure (IOP), a major glaucoma risk factor, has been a mainstay of research into mechanisms of glaucomatous optic nerve damage for decades. Methods that produce sustained...
4.
Lozano D, Cepurna W, Johnson E, Morrison J
Exp Eye Res . 2024 Sep; 248:110106. PMID: 39307451
Our purpose was to develop a protocol for prolonged anesthesia in mice and evaluate optic nerve axon injury in response to 4 h of controlled elevation of intraocular pressure (CEI)....
5.
Lozano D, Yang Y, Cepurna W, Smoody B, Ing E, Morrison J, et al.
Invest Ophthalmol Vis Sci . 2024 May; 65(5):41. PMID: 38809543
Purpose: The rat controlled elevation of intraocular pressure (CEI) model allows study of in vivo responses to short-term exposure to defined intraocular pressures (IOP). In this study, we used NanoString...
6.
Lozano D, Yang Y, Cepurna W, Smoody B, Ing E, Morrison J, et al.
bioRxiv . 2024 Feb; PMID: 38370622
Purpose: The rat Controlled Elevation of Intraocular pressure (CEI) model allows study of responses to defined intraocular pressures (IOP). In this study, we use Nanostring technology to investigate IOP-related gene...
7.
Lozano D, Jayaram H, Cepurna W, Tehrani S, Gao L, Fei S, et al.
Invest Ophthalmol Vis Sci . 2023 Jul; 64(10):4. PMID: 37405758
Purpose: To clarify the optic nerve head (ONH) gene expression responses associated with a single, axon-damaging exposure to elevated IOP in relation to the composite cellular events previously identified in...
8.
Pi S, Wang B, Gao M, Cepurna W, Lozano D, Morrison J, et al.
Invest Ophthalmol Vis Sci . 2023 Apr; 64(4):17. PMID: 37057973
Purpose: To characterize rat retinal responses after optic nerve transection (ONT) by visible-light optical coherence tomography (vis-OCT). Methods: Unilateral ONT was performed in Brown Norway rats (n = 8). In...
9.
Ing E, Lozano D, Cepurna W, Chan F, Yang Y, Morrison J, et al.
Exp Eye Res . 2023 Feb; 228:109367. PMID: 36740159
Glaucoma is often associated with elevated intraocular pressure (IOP), generally due to obstruction of aqueous humor outflow within the trabecular meshwork (TM). Despite many decades of research, the molecular cause...
10.
Pi S, Hormel T, Wang B, Bailey S, Hwang T, Huang D, et al.
Biomed Opt Express . 2022 Oct; 13(9):4889-4906. PMID: 36187263
Optical coherence tomography (OCT) is widely used in ophthalmic practice because it can visualize retinal structure and vasculature in vivo and 3-dimensionally (3D). Even though OCT procedures yield data volumes,...