John A Faulkner
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Explore the profile of John A Faulkner including associated specialties, affiliations and a list of published articles.
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48
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2047
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Recent Articles
1.
Deepa S, Van Remmen H, Brooks S, Faulkner J, Larkin L, McArdle A, et al.
Free Radic Biol Med
. 2019 Jan;
132:19-23.
PMID: 30670156
Mice lacking Cu/Zn-superoxide dismutase (Sod1 or Sod1KO mice) show high levels of oxidative stress/damage and a 30% decrease in lifespan. The Sod1KO mice also show many phenotypes of accelerated aging...
2.
Mendias C, Bakhurin K, Gumucio J, Shallal-Ayzin M, Davis C, Faulkner J
Aging Cell
. 2015 Mar;
14(4):704-6.
PMID: 25808276
The molecular mechanisms behind aging-related declines in muscle function are not well understood, but the growth factor myostatin (MSTN) appears to play an important role in this process. Additionally, epidemiological...
3.
Russell K, Ng R, Faulkner J, Claflin D, Mendias C
Exp Gerontol
. 2015 Mar;
65:42-5.
PMID: 25762422
A progressive loss of skeletal muscle mass and force generating capacity occurs with aging. Mice are commonly used in the study of aging-associated changes in muscle size and strength, with...
4.
Kung T, Cederna P, Van der Meulen J, Urbanchek M, Kuzon Jr W, Faulkner J
J Gerontol A Biol Sci Med Sci
. 2013 Oct;
69(6):657-65.
PMID: 24077596
Sarcopenia leads to many changes in skeletal muscle that contribute to atrophy, force deficits, and subsequent frailty. The purpose of this study was to characterize motor unit remodeling related to...
5.
Larkin L, Hanes M, Kayupov E, Claflin D, Faulkner J, Brooks S
Age (Dordr)
. 2012 Jun;
35(4):1173-81.
PMID: 22696118
Mice deficient in Cu,Zn superoxide dismutase (Sod1 (-/-) mice) demonstrate elevated oxidative stress associated with rapid age-related declines in muscle mass and force. The decline in mass for muscles of...
6.
Claflin D, Larkin L, Cederna P, Horowitz J, Alexander N, Cole N, et al.
J Appl Physiol (1985)
. 2011 Jul;
111(4):1021-30.
PMID: 21799130
A two-arm, prospective, randomized, controlled trial study was conducted to investigate the effects of movement velocity during progressive resistance training (PRT) on the size and contractile properties of individual fibers...
7.
Palmer M, Claflin D, Faulkner J, Panchangam A
J Muscle Res Cell Motil
. 2011 Jun;
32(1):39-48.
PMID: 21710358
Tension and regional average sarcomere length (L(s)) behavior were examined during repeated stretches of single, permeabilized, relaxed muscle fibers isolated from the soleus muscles of rats. We tested the hypothesis...
8.
Ramaswamy K, Palmer M, Van der Meulen J, Renoux A, Kostrominova T, Michele D, et al.
J Physiol
. 2011 Jan;
589(Pt 5):1195-208.
PMID: 21224224
The dystrophin–glycoprotein complex (DGC) provides an essential link from the muscle fibre cytoskeleton to the extracellular matrix. In dystrophic humans and mdx mice, mutations in the dystrophin gene disrupt the...
9.
Vasilaki A, Simpson D, McArdle F, McLean L, Beynon R, Van Remmen H, et al.
Proteomics Clin Appl
. 2010 Dec;
1(4):362-72.
PMID: 21136689
Oxidation of skeletal muscle proteins has been reported to occur following contractions, with ageing, and with a variety of disease states, but the nature of the oxidised proteins has not...
10.
Han R, Frett E, Levy J, Rader E, Lueck J, Bansal D, et al.
J Clin Invest
. 2010 Nov;
120(12):4366-74.
PMID: 21060153
Mutations in the dysferlin gene underlie a group of autosomal recessive muscle-wasting disorders denoted as dysferlinopathies. Dysferlin has been shown to play roles in muscle membrane repair and muscle regeneration,...