John A Alberta
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Explore the profile of John A Alberta including associated specialties, affiliations and a list of published articles.
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21
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1723
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Recent Articles
1.
Reitman Z, Paolella B, Bergthold G, Pelton K, Becker S, Jones R, et al.
Nat Commun
. 2019 Aug;
10(1):3731.
PMID: 31427603
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in six PAs using methods that enabled...
2.
Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, et al.
Cancer Res
. 2018 May;
78(14):4007-4021.
PMID: 29760046
Aberrant chromatin remodeling and activation of the PI3K pathway have been identified as important mediators of pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) pathogenesis. As inhibition of...
3.
Singh S, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, et al.
Cell Rep
. 2017 Jun;
19(11):2410-2412.
PMID: 28614724
No abstract available.
4.
Zhou J, Tien A, Alberta J, Ficarro S, Griveau A, Sun Y, et al.
Cell Rep
. 2017 Mar;
18(13):3167-3177.
PMID: 28355568
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of...
5.
Paolella B, Gibson W, Urbanski L, Alberta J, Zack T, Bandopadhayay P, et al.
Elife
. 2017 Feb;
6.
PMID: 28177281
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically...
6.
Sun Y, Alberta J, Pilarz C, Calligaris D, Chadwick E, Ramkissoon S, et al.
Neuro Oncol
. 2017 Jan;
19(6):774-785.
PMID: 28082416
Background: Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood-brain...
7.
Edwards A, Meijer D, Guerra R, Molenaar R, Alberta J, Bernal F, et al.
ACS Chem Biol
. 2016 Sep;
11(11):3146-3153.
PMID: 27643505
Basic helix-loop-helix (bHLH) transcription factors play critical roles in organism development and disease by regulating cell proliferation and differentiation. Transcriptional activity, whether by bHLH homo- or heterodimerization, is dependent on...
8.
Singh S, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, et al.
Cell Rep
. 2016 Jul;
16(4):950-966.
PMID: 27396340
In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown...
9.
Meijer D, Sun Y, Liu T, Kane M, Alberta J, Adelmant G, et al.
J Neurosci
. 2014 Jun;
34(25):8507-18.
PMID: 24948806
The bHLH transcription factor Olig2 is expressed in cycling neural progenitor cells but also in terminally differentiated, myelinating oligodendrocytes. Sustained expression of Olig2 is counterintuitive because all known functions of...
10.
Silbereis J, Nobuta H, Tsai H, Heine V, McKinsey G, Meijer D, et al.
Neuron
. 2014 Feb;
81(3):574-87.
PMID: 24507192
Abnormal GABAergic interneuron density, and imbalance of excitatory versus inhibitory tone, is thought to result in epilepsy, neurodevelopmental disorders, and psychiatric disease. Recent studies indicate that interneuron cortical density is...