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John-Olof Thorngren

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Citations 133
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Recent Articles
1.
Sparreman Mikus M, Kolmert J, Andersson L, Ostling J, Knowles R, Gomez C, et al.
Eur Respir J . 2021 Nov; 59(2). PMID: 34737220
Rationale: Asthma phenotyping requires novel biomarker discovery. Objectives: To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of...
2.
Schulze J, Pettersson-Bohlin K, Thorngren J, Ekstrom L
Drug Test Anal . 2021 Apr; 13(8):1576-1579. PMID: 33864421
To detect doping with pseudo-endogenous anabolic steroids in sports, a urinary steroid profile with glucuronidated plus unconjugated androgens is used. In addition to analyze androgen glucuronide metabolites, it can be...
3.
Alahmadi F, Simpson A, Gomez C, Ericsson M, Thorngren J, Wheelock C, et al.
Chest . 2021 Feb; 160(1):53-64. PMID: 33610577
Background: Although estimates of suboptimal adherence to oral corticosteroids in asthma range from 30% to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma...
4.
Kolmert J, Gomez C, Balgoma D, Sjodin M, Bood J, Konradsen J, et al.
Am J Respir Crit Care Med . 2020 Jul; 203(1):37-53. PMID: 32667261
New approaches are needed to guide personalized treatment of asthma. To test if urinary eicosanoid metabolites can direct asthma phenotyping. Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes...
5.
Eklund E, Ekstrom L, Thorngren J, Ericsson M, Berglund B, Linden Hirschberg A
Front Endocrinol (Lausanne) . 2020 Jun; 11:292. PMID: 32528408
The second to fourth digit ratio (2D:4D ratio) is suggested to be a negative correlate of prenatal testosterone. Little is known about the role of the 2D:4D ratio in relation...
6.
Gadot Y, Thorngren J, Eklund E, Ekstrom L, Rane A
J Endocr Soc . 2018 Jun; 2(7):597-608. PMID: 29942924
Objective: To investigate the excretion and conjugation profile of testosterone (T), Epitestosterone (EpiT), and other androgen metabolites in different phases of pregnancy and postpregnancy as a reflection of the "androgenic...
7.
Mullen J, Thorngren J, Schulze J, Ericsson M, Garevik N, Lehtihet M, et al.
Drug Test Anal . 2016 Oct; 9(7):1034-1042. PMID: 27758048
Today's doping tests involving longitudinal monitoring of steroid profiles are difficult in women. Women have more complex hormonal fluctuations than men and commonly take drugs such as hormonal contraceptives that...
8.
Schulze J, Johansson M, Thorngren J, Garle M, Rane A, Ekstrom L
Front Endocrinol (Lausanne) . 2013 Jul; 4:88. PMID: 23874324
Human cytosolic sulfotransferases (SULT) 2A1 is the main enzyme involved in the sulfate conjugation of dehydroepiandrosterone, a weak androgen, and the main androgen precursor, whereas estrogens are mainly conjugated by...
9.
Lundmark J, Garevik N, Thorngren J, Garle M, Ekstrom L, Rane A, et al.
Front Endocrinol (Lausanne) . 2013 May; 4:51. PMID: 23720652
The UDP Glucuronosyl Transferase (UGT) enzymes are important in the pharmacokinetics, and conjugation, of a variety of drugs including non-steroidal anti-inflammatory drugs (NSAIDs) as well as anabolic androgenic steroids (AAS)....
10.
Ekstrom L, Cevenini L, Michelini E, Schulze J, Thorngren J, Belanger A, et al.
Eur J Clin Invest . 2013 Jan; 43(3):248-55. PMID: 23294483
Background: We investigated the androgen receptor (AR) bioluminescense response in serum and urine before and after testosterone challenge in different genotypes of the UGT2B17 enzyme, which catalyses testosterone glucuronidation. Material...