Johannes Mosbacher
Overview
Explore the profile of Johannes Mosbacher including associated specialties, affiliations and a list of published articles.
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21
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1750
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Recent Articles
1.
Zurfluh L, Santos S, Ruppen A, Mosbacher J, Haslinger C, Ochsenbein-Kolble N, et al.
Biomed Pharmacother
. 2025 Feb;
184:117919.
PMID: 39983434
Preparations of Bryophyllum pinnatum have been used as a well-tolerated treatment of preterm labor, initially in anthroposophic hospitals and, more recently, also in conventional settings. In vitro studies with human...
2.
Kruta J, Carapito R, Trendelenburg M, Martin T, Rizzi M, Voll R, et al.
Sci Rep
. 2024 Nov;
14(1):27848.
PMID: 39537649
Early and accurate diagnosis is crucial to prevent disease development and define therapeutic strategies. Due to predominantly unspecific symptoms, diagnosis of autoimmune diseases (AID) is notoriously challenging. Clinical decision support...
3.
Zurfluh L, Duvaud L, Inci N, Potterat O, Simoes-Wust A, Mosbacher J
Planta Med
. 2024 Apr;
90(10):757-765.
PMID: 38599625
The medicinal plant was previously shown to block oxytocin (OT)-induced signals in myometrial cells, consistent with its tocolytic effect observed in patients. OT activates not only OT receptors but also...
4.
Gygax D, Eigenmann K, Suter C, Hurzeler M, Mahmoud A, Mosbacher J, et al.
Chimia (Aarau)
. 2023 Dec;
77(9):616-619.
PMID: 38047837
In this work, we investigated the technical feasibility of 'on-demand' production of selected drugs to cover their demand for a time window of 90 days. We focused on two sub-processes...
5.
Bezencon O, Siegrist R, Heidmann B, Pozzi D, Stamm S, Remen L, et al.
Chimia (Aarau)
. 2017 Oct;
71(10):722-729.
PMID: 29070417
We describe the discovery and optimization of new, brain-penetrant T-type calcium channel blockers. We present optimized compounds with excellent efficacy in a rodent model of generalized absence-like epilepsy. Along the...
6.
Remen L, Bezencon O, Simons L, Gaston R, Downing D, Gatfield J, et al.
J Med Chem
. 2016 Sep;
59(18):8398-411.
PMID: 27579577
A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated...
7.
Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, et al.
Neuropharmacology
. 2013 May;
72:215-23.
PMID: 23664812
Glutamate transmission and synaptic plasticity in the amygdala are essential for the learning and expression of conditioned fear. Glutamate activates both ionotropic glutamate receptors and eight subtypes of metabotropic glutamate...
8.
Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, et al.
J Biomol Screen
. 2012 Aug;
17(9):1264-72.
PMID: 22923790
Neurons derived from human-induced pluripotent stem cells were characterized using manual and automated patch-clamp recordings. These cells expressed voltage-gated Na(+) (Na(v)), Ca(2+) (Ca(v)), and K(+) (K(v)) channels as expected from...
9.
Chaperon F, Fendt M, Kelly P, Lingenhoehl K, Mosbacher J, Olpe H, et al.
PLoS One
. 2012 Apr;
7(4):e34963.
PMID: 22509372
Links between synaptic plasticity in the lateral amygdala (LA) and Pavlovian fear learning are well established. Neuropeptides including gastrin-releasing peptide (GRP) can modulate LA function. GRP increases inhibition in the...
10.
Hintermann S, Hurth K, Nozulak J, Tintelnot-Blomley M, Aichholz R, Blanz J, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(5):1523-6.
PMID: 21277199
A novel series of agonists at the benzodiazepine binding site of the GABA(A) receptor was prepared by functionalizing a known template. Adding substituents to the pyrazolone-oxygen of CGS-9896 led to...