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Johannes M van Rooyen

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Articles 67
Citations 500
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Gafane-Matemane L, Kruger R, van Rooyen J, Gona P, Schutte A
J Cardiovasc Dev Dis . 2022 May; 9(5). PMID: 35621841
This study aims to compare soluble (pro)renin receptor [s(P)RR] levels between black and white adults and to explore the associations of left ventricular (LV) structure and function with s(P)RR in...
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Breet Y, Craig A, Smith W, Botha-Le Roux S, Gafane-Matemane L, Brits S, et al.
Front Pediatr . 2022 Jan; 9:795301. PMID: 34976899
Cross-talk between the macro-and microvasculature is considered an important contributor to target organ damage. Previous findings were predominantly in adult populations and investigation into this mechanism in children may provide...
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van Rooyen J, Poglitsch M, Mels C, Huisman H, Gafane-Matemane L, Le Roux S, et al.
J Hum Hypertens . 2021 Jun; 36(8):711-717. PMID: 34172825
Exogenous estrogens and progestins may affect the components of the renin-angiotensin-aldosterone system (RAAS). Changes in ventricular blood volume are associated with increased secretion of N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP),...
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Kochli S, Schutte A, Botha-Le Roux S, Gafane-Matemane L, Smith W, van Rooyen J, et al.
Nutr Metab Cardiovasc Dis . 2021 Feb; 31(4):1071-1080. PMID: 33549447
Background And Aims: Heart rate variability (HRV) is a main determinant of autonomic function and related to the development of hypertension and cardiovascular (CV) disease. Hypertension develops in black populations...
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van Niekerk E, Botha Le Roux S, Atzler D, Schwedhelm E, Boger R, van Rooyen J, et al.
J Hum Hypertens . 2020 May; 35(4):325-333. PMID: 32382032
Physical activity affects the vasculature through mechanisms related to nitric oxide bioavailability, oxidative stress, and inflammation; with endothelial function at the centre of this triad. In a South African setting,...
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van Rooyen J, Poglitsch M, Huisman H, Gafane-Matemane L, Breet Y, Malan L
Cardiovasc J Afr . 2019 Nov; 31(3):130-135. PMID: 31781716
Introduction: Black populations may be more likely to have primary aldosteronism (PA) due to adrenal hyperplasia or other forms of adrenal hyperactivity, with suppressed renin levels and high levels of...
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Swart R, Schutte A, van Rooyen J, Smith W, Mels C
J Am Coll Nutr . 2019 Mar; 38(7):614-622. PMID: 30822227
Selenium plays an important physiological role as component for antioxidant selenoproteins such as glutathione peroxidase (GPx). Since oxidative stress contributes to hypertension development, it is likely that selenium deficiency may...
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Gafane-Matemane L, van Rooyen J, Schutte R, Schutte A
Cardiovasc J Afr . 2019 Feb; 30(1):34-40. PMID: 30720841
Introduction: Hypertension, particularly in black populations, is often accompanied by augmented sympathetic nervous system activity and suppressed renin activity, indicative of possible blood pressure (BP) dysregulation. The potential role of...