Johannes H Hegemann
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Explore the profile of Johannes H Hegemann including associated specialties, affiliations and a list of published articles.
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47
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2601
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Recent Articles
1.
Kocher F, Hegemann J
Front Cell Infect Microbiol
. 2025 Feb;
14:1519883.
PMID: 39931630
Attachment and uptake into host cells are pivotal steps in the life cycle of the , a family of obligate intracellular pathogens. possesses a family of nine polymorphic membrane proteins...
2.
Wintgens S, Muller J, Drees F, Spona D, Bonda L, Hartmann L, et al.
Macromol Biosci
. 2025 Jan;
e2400443.
PMID: 39838590
Glycosaminoglycans (GAGs) play a pivotal role in pathogen attachment and entry into host cells, where the interaction with GAGs is critical for a diverse range of bacteria and viruses. This...
3.
Kocher F, Applegate V, Reiners J, Port A, Spona D, Hansch S, et al.
Nat Commun
. 2024 Aug;
15(1):7294.
PMID: 39181890
To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell's plasma membrane and recruit several pivotal endocytic host proteins....
4.
Hohler M, Alcazar-Roman A, Schenk K, Aguirre-Huamani M, Braun C, Zrieq R, et al.
J Cell Sci
. 2024 Aug;
137(17).
PMID: 39099397
To propagate within a eukaryotic cell, pathogenic bacteria hijack and remodulate host cell functions. The Gram-negative obligate intracellular Chlamydiaceae, which pose a serious threat to human and animal health, attach...
5.
Spona D, Hanisch P, Hegemann J, Molleken K
Commun Biol
. 2023 May;
6(1):520.
PMID: 37179401
Uptake of obligate intracellular bacterial pathogens into mammalian epithelial cells is critically dependent on modulation of the host's endocytic machinery. It is an open question how the invading pathogens generate...
6.
Wevers C, Hohler M, Alcazar-Roman A, Hegemann J, Fleig U
Int J Mol Sci
. 2023 Apr;
24(8).
PMID: 37108781
Bacterial pathogens have evolved intricate ways to manipulate the host to support infection. Here, we systematically assessed the importance of the microtubule cytoskeleton for infection by , which are obligate...
7.
Erenburg I, Hansch S, Chacko F, Hamacher A, Wintgens S, Stuhldreier F, et al.
Sci Rep
. 2022 Oct;
12(1):17825.
PMID: 36280777
Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I...
8.
Li X, Zuo Z, Wang Y, Hegemann J, He C
Front Immunol
. 2022 Feb;
12:818487.
PMID: 35173712
() is an obligate intracellular, gram-negative bacterium, and mainly causes systemic disease in psittacine birds, domestic poultry, and wild fowl. The pathogen is threating to human beings due to closely...
9.
Favaroni A, Hegemann J
Front Microbiol
. 2021 Aug;
12:709724.
PMID: 34349750
are Gram-negative, obligate intracellular bacteria, which infect animals and humans. Adhesion to host cells, the first step in the infection process, is mediated by polymorphic membrane proteins (Pmps). Pmps constitute...
10.
Lanfermann C, Wintgens S, Ebensen T, Kohn M, Laudeley R, Schulze K, et al.
Vaccines (Basel)
. 2021 Jul;
9(6).
PMID: 34204170
is the most frequent sexually-transmitted disease-causing bacterium. Urogenital serovars of this intracellular pathogen lead to urethritis and cervicitis. Ascending infections result in pelvic inflammatory disease, salpingitis, and oophoritis. One of...