Johannes Geiger
Overview
Explore the profile of Johannes Geiger including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
240
Followers
0
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Recent Articles
1.
Vishwanath S, Carnell G, Billmeier M, Ohlendorf L, Neckermann P, Asbach B, et al.
NPJ Vaccines
. 2024 Sep;
9(1):164.
PMID: 39251608
Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable...
2.
Hamblet C, Bjorhall K, Busch S, Gehrmann U, Oberg L, Kubisch-Dohmen R, et al.
Antioxidants (Basel)
. 2024 Aug;
13(8).
PMID: 39199170
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases. Cellular...
3.
Vishwanath S, Carnell G, Ferrari M, Asbach B, Billmeier M, George C, et al.
Nat Biomed Eng
. 2023 Sep;
9(2):153-166.
PMID: 37749309
The threat of spillovers of coronaviruses associated with the severe acute respiratory syndrome (SARS) from animals to humans necessitates vaccines that offer broader protection from sarbecoviruses. By leveraging a viral-genome-informed...
4.
De La Vega R, van Griensven M, Zhang W, Coenen M, Nagelli C, Panos J, et al.
Sci Adv
. 2022 Feb;
8(7):eabl6242.
PMID: 35171668
Large segmental osseous defects heal poorly. Recombinant, human bone morphogenetic protein-2 (rhBMP-2) is used clinically to promote bone healing, but it is applied at very high doses that cause adverse...
5.
Edwards N, McCaughey-Chapman A, Combrinck C, Geiger J, Connor B
Stem Cells Dev
. 2021 Dec;
31(3-4):78-89.
PMID: 34963331
The development of human cell-based platforms for disease modeling, drug discovery, and regenerative therapy relies on robust and practical methods to derive high yields of relevant neuronal subtypes. Direct reprogramming...
6.
Romito M, Juillerat A, Kok Y, Hildenbeutel M, Rhiel M, Andrieux G, et al.
Biotechnol J
. 2020 Oct;
16(1):e2000023.
PMID: 33103367
Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell grafts...
7.
Trepotec Z, Geiger J, Plank C, Aneja M, Rudolph C
RNA
. 2019 Jan;
25(4):507-518.
PMID: 30647100
Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A)...
8.
Connor B, Firmin E, McCaughey-Chapman A, Monk R, Lee K, Liot S, et al.
Heliyon
. 2018 Nov;
4(11):e00918.
PMID: 30450440
Direct reprogramming offers a unique approach by which to generate neural lineages for the study and treatment of neurological disorders. Our objective is to develop a clinically viable reprogramming strategy...
9.
Trepotec Z, Aneja M, Geiger J, Hasenpusch G, Plank C, Rudolph C
Tissue Eng Part A
. 2018 Apr;
25(1-2):69-79.
PMID: 29638193
The 5'-untranslated region (5'-UTR) of mRNA contains structural elements, which are recognized by cell-specific RNA-binding proteins, thereby affecting the translation of the molecule. The activation of an innate immune response...
10.
Holstein M, Mesa-Nunez C, Miskey C, Almarza E, Poletti V, Schmeer M, et al.
Mol Ther
. 2018 Mar;
26(4):1137-1153.
PMID: 29503198
The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications. However, efficient correction...