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Johanna M Virta

Explore the profile of Johanna M Virta including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 28
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Recent Articles
1.
Vickery H, Virta J, Konstantinidou M, Arkin M
SLAS Discov . 2024 May; 29(5):100165. PMID: 38797286
We report the development of a 384-well formatted NanoBRET assay to characterize molecular glues of 14-3-3/client interactions in living cells. The seven isoforms of 14-3-3 are dimeric hub proteins with...
2.
Kenanova D, Visser E, Virta J, Sijbesma E, Centorrino F, Vickery H, et al.
ACS Cent Sci . 2023 May; 9(5):937-946. PMID: 37252362
Dysregulation of protein-protein interactions (PPIs) commonly leads to disease. PPI stabilization has only recently been systematically explored for drug discovery despite being a powerful approach to selectively target intrinsically disordered...
3.
Montemayor E, Virta J, Hayes S, Nomura Y, Brow D, Butcher S
RNA . 2020 Jun; 26(10):1400-1413. PMID: 32518066
Eukaryotes possess eight highly conserved Lsm (like Sm) proteins that assemble into circular, heteroheptameric complexes, bind RNA, and direct a diverse range of biological processes. Among the many essential functions...
4.
Nomura Y, Montemayor E, Virta J, Hayes S, Butcher S
Nucleic Acids Res . 2019 Dec; 48(3):1423-1434. PMID: 31832688
U6 snRNA undergoes post-transcriptional 3' end modification prior to incorporation into the active site of spliceosomes. The responsible exoribonuclease is Usb1, which removes nucleotides from the 3' end of U6...
5.
Montemayor E, Virta J, Hagler L, Zimmerman S, Butcher S
Acta Crystallogr F Struct Biol Commun . 2019 Oct; 75(Pt 10):652-656. PMID: 31584014
The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1....