Johann M Rohwer
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Explore the profile of Johann M Rohwer including associated specialties, affiliations and a list of published articles.
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41
Citations
548
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Recent Articles
1.
Sauro H, Agmon E, Blinov M, Gennari J, Hellerstein J, Heydarabadipour A, et al.
ArXiv
. 2025 Mar;
PMID: 40034129
Guidelines for managing scientific data have been established under the FAIR principles requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data...
2.
Gonzalez-Cabanelas D, Perreca E, Rohwer J, Schmidt A, Engl T, Raguschke B, et al.
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673766
The plastidic 2-C-methylerythritol 4-phosphate (MEP) pathway supplies the precursors of a large variety of essential plant isoprenoids, but its regulation is still not well understood. Using metabolic control analysis (MCA),...
3.
Rohwer J
Essays Biochem
. 2024 Apr;
68(1):1-3.
PMID: 38662436
Computational biology is a diverse research field that has gained increasing importance over the last two decades. Broadly, it aims to apply computational approaches to advance our understanding of biological...
4.
Lind D, Naidoo K, Tomalin L, Rohwer J, Veal E, Pillay C
Free Radic Biol Med
. 2024 Apr;
218:16-25.
PMID: 38574974
A critical feature of the cellular antioxidant response is the induction of gene expression by redox-sensitive transcription factors. In many cells, activating these transcription factors is a dynamic process involving...
5.
Pillay C, Rohwer J
Essays Biochem
. 2024 Feb;
68(1):27-39.
PMID: 38356400
Thioredoxin, glutaredoxin and peroxiredoxin systems play central roles in redox regulation, signaling and metabolism in cells. In these systems, reducing equivalents from NAD(P)H are transferred by coupled thiol-disulfide exchange reactions...
6.
Barry C, Pillay C, Rohwer J
Antioxidants (Basel)
. 2023 Sep;
12(9).
PMID: 37760010
Peroxiredoxins play central roles in the detoxification of reactive oxygen species and have been modelled across multiple organisms using a variety of kinetic methods. However, the peroxiredoxin dimer-to-decamer transition has...
7.
Pillay C, John N, Barry C, Mthethwa L, Rohwer J
Redox Biol
. 2023 Jul;
65:102802.
PMID: 37423162
Infectious diseases are a significant health burden for developing countries, particularly with the rise of multidrug resistance. There is an urgent need to elucidate the factors underlying the persistence of...
8.
Lauterbach S, Dienhart H, Range J, Malzacher S, Sporing J, Rother D, et al.
Nat Methods
. 2023 Feb;
20(3):400-402.
PMID: 36759590
The design of biocatalytic reaction systems is highly complex owing to the dependency of the estimated kinetic parameters on the enzyme, the reaction conditions, and the modeling method. Consequently, reproducibility...
9.
BioSimulators: a central registry of simulation engines and services for recommending specific tools
Shaikh B, Smith L, Vasilescu D, Marupilla G, Wilson M, Agmon E, et al.
Nucleic Acids Res
. 2022 May;
50(W1):W108-W114.
PMID: 35524558
Computational models have great potential to accelerate bioscience, bioengineering, and medicine. However, it remains challenging to reproduce and reuse simulations, in part, because the numerous formats and methods for simulating...
10.
Rohwer J, Schutte C, van der Sluis R
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33803916
The glycine conjugation pathway in humans is involved in the metabolism of natural substrates and the detoxification of xenobiotics. The interactions between the various substrates in this pathway and their...