Johann M Rohwer
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Explore the profile of Johann M Rohwer including associated specialties, affiliations and a list of published articles.
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41
Citations
548
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Recent Articles
11.
Padayachee L, Rohwer J, Pillay C
Arch Biochem Biophys
. 2019 Dec;
680:108231.
PMID: 31877266
The thioredoxin system plays a central role in intracellular redox regulation and its dysregulation is associated with a number of pathologies. However, the connectivity within this system poses a significant...
12.
Christensen C, Hofmeyr J, Rohwer J
PLoS One
. 2018 Nov;
13(11):e0207983.
PMID: 30485345
High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system's components is therefore...
13.
Swainston N, Baici A, Bakker B, Cornish-Bowden A, Fitzpatrick P, Halling P, et al.
FEBS J
. 2018 Mar;
285(12):2193-2204.
PMID: 29498804
Standards for reporting enzymology data (STRENDA) DB is a validation and storage system for enzyme function data that incorporates the STRENDA Guidelines. It provides authors who are preparing a manuscript...
14.
Christensen C, Hofmeyr J, Rohwer J
Bioinformatics
. 2017 Oct;
34(1):124-125.
PMID: 28968872
Summary: PySCeSToolbox is an extension to the Python Simulator for Cellular Systems (PySCeS) that includes tools for performing generalized supply-demand analysis, symbolic metabolic control analysis, and a framework for investigating...
15.
Pillay C, Eagling B, Driscoll S, Rohwer J
Free Radic Biol Med
. 2016 May;
96:290-303.
PMID: 27151506
Redox signaling is now recognized as an important regulatory mechanism for a number of cellular processes including the antioxidant response, phosphokinase signal transduction and redox metabolism. While there has been...
16.
Christensen C, Hofmeyr J, Rohwer J
BMC Syst Biol
. 2015 Dec;
9:89.
PMID: 26635009
Background: Generalised supply-demand analysis is a conceptual framework that views metabolism as a molecular economy. Metabolic pathways are partitioned into so-called supply and demand blocks that produce and consume a...
17.
Mashamaite L, Rohwer J, Pillay C
Biosci Rep
. 2014 Dec;
35(1).
PMID: 25514238
Glutathionylation plays a central role in cellular redox regulation and anti-oxidative defence. Grx (Glutaredoxins) are primarily responsible for reversing glutathionylation and their activity therefore affects a range of cellular processes,...
18.
Wright L, Rohwer J, Ghirardo A, Hammerbacher A, Ortiz-Alcaide M, Raguschke B, et al.
Plant Physiol
. 2014 Jul;
165(4):1488-1504.
PMID: 24987018
The 2-C-methylerythritol 4-phosphate (MEP) pathway supplies precursors for plastidial isoprenoid biosynthesis including carotenoids, redox cofactor side chains, and biogenic volatile organic compounds. We examined the first enzyme of this pathway,...
19.
Palm D, Rohwer J, Hofmeyr J
Biochem J
. 2014 Jun;
462(3):525-37.
PMID: 24969542
Several enzymes have been described that undergo both allosteric and covalent regulation, but, to date, there exists no succinct kinetic description that is able to account for both of these...
20.
Eicher J, Snoep J, Rohwer J
Metabolites
. 2014 Jun;
2(4):818-43.
PMID: 24957764
Enzyme kinetics for systems biology should ideally yield information about the enzyme's activity under in vivo conditions, including such reaction features as substrate cooperativity, reversibility and allostery, and be applicable...