Johan Memelink
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Explore the profile of Johan Memelink including associated specialties, affiliations and a list of published articles.
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33
Citations
1942
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Recent Articles
1.
Chen Y, Klinkhamer P, Memelink J, Vrieling K
BMC Plant Biol
. 2020 Jul;
20(1):342.
PMID: 32689941
Background: Collectively, plants produce a huge variety of secondary metabolites (SMs) which are involved in the adaptation of plants to biotic and abiotic stresses. The most characteristic feature of SMs...
2.
An E. coli biosensor for screening of cDNA libraries for isochorismate pyruvate lyase-encoding cDNAs
Zhou Y, Memelink J, Linthorst H
Mol Genet Genomics
. 2018 May;
293(5):1181-1190.
PMID: 29796759
Salicylic acid (SA) is an essential hormone for development and induced defense against biotrophic pathogens in plants. The formation of SA mainly derives from chorismate via demonstrated isochorismate synthase (ICS)...
3.
Van Moerkercke A, Steensma P, Gariboldi I, Espoz J, Purnama P, Schweizer F, et al.
Plant J
. 2016 Jun;
88(1):3-12.
PMID: 27342401
Monoterpenoid indole alkaloids (MIAs) are produced as plant defence compounds. In the medicinal plant Catharanthus roseus, they comprise the anticancer compounds vinblastine and vincristine. The iridoid (monoterpenoid) pathway forms one...
4.
Zhou M, Memelink J
Biotechnol Adv
. 2016 Feb;
34(4):441-449.
PMID: 26876016
Plants produce a large variety of secondary metabolites including alkaloids, glucosinolates, terpenoids and phenylpropanoids. These compounds play key roles in plant-environment interactions and many of them have pharmacological activity in...
5.
Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, et al.
Proc Natl Acad Sci U S A
. 2015 Jun;
112(26):8130-5.
PMID: 26080427
Plants make specialized bioactive metabolites to defend themselves against attackers. The conserved control mechanisms are based on transcriptional activation of the respective plant species-specific biosynthetic pathways by the phytohormone jasmonate....
6.
Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Muller-Uri F, et al.
Mol Plant
. 2015 Jan;
8(1):136-52.
PMID: 25578278
Catharanthus roseus, the Madagascar periwinkle, synthesizes bioactive monoterpenoid indole alkaloids, including the anti-cancer drugs vinblastine and vincristine. The monoterpenoid branch of the alkaloid pathway leads to the secoiridoid secologanin and...
7.
Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Muller-Uri F, et al.
Mol Plant
. 2014 Sep;
PMID: 25239067
Catharanthus roseus, the Madagascar periwinkle, synthesizes bioactive monoterpenoid indole alkaloids, among which the anti-cancer drugs vinblastine and vincristine. The monoterpenoid branch of the alkaloid pathway leads to the secoiridoid secologanin...
8.
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, et al.
Nat Commun
. 2014 Apr;
5:3606.
PMID: 24710322
The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and...
9.
Dong L, Miettinen K, Goedbloed M, Verstappen F, Voster A, Jongsma M, et al.
Metab Eng
. 2013 Sep;
20:198-211.
PMID: 24060453
Two geraniol synthases (GES), from Valeriana officinalis (VoGES) and Lippia dulcis (LdGES), were isolated and were shown to have geraniol biosynthetic activity with Km values of 32 µM and 51...
10.
Hofer R, Dong L, Andre F, Ginglinger J, Lugan R, Gavira C, et al.
Metab Eng
. 2013 Aug;
20:221-32.
PMID: 23933465
The geraniol-derived (seco)iridoid skeleton is a precursor for a large group of bioactive compounds with diverse therapeutic applications, including the widely used anticancer molecule vinblastine. Despite of this economic prospect,...