Joerg Schaarschmidt
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Explore the profile of Joerg Schaarschmidt including associated specialties, affiliations and a list of published articles.
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9
Citations
229
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Recent Articles
1.
Anzt H, Bach F, Druskat S, Loffler F, Loewe A, Renard B, et al.
F1000Res
. 2021 Feb;
9:295.
PMID: 33552475
Research software has become a central asset in academic research. It optimizes existing and enables new research methods, implements and embeds research knowledge, and constitutes an essential research product in...
2.
Morris C, Andreetto P, Banci L, Bonvin A, Chojnowski G, Del Cano L, et al.
J Struct Biol X
. 2020 Jul;
1:100006.
PMID: 32647812
The West-Life project (https://about.west-life.eu/) is a Horizon 2020 project funded by the European Commission to provide data processing and data management services for the international community of structural biologists, and...
3.
Vangone A, Schaarschmidt J, Koukos P, Geng C, Citro N, Trellet M, et al.
Bioinformatics
. 2019 May;
35(9):1585-1587.
PMID: 31051038
Summary: Recently we published PROtein binDIng enerGY (PRODIGY), a web-server for the prediction of binding affinity in protein-protein complexes. By using a combination of simple structural properties, such as the...
4.
Arenas J, Pupo E, de Jonge E, Perez-Ortega J, Schaarschmidt J, Van der Ley P, et al.
J Biol Chem
. 2019 Mar;
294(20):7982-7989.
PMID: 30926608
Lipopolysaccharides are anchored to the outer membrane of Gram-negative bacteria by a hydrophobic moiety known as lipid A, which potently activates the host innate immune response. Lipid A of ,...
5.
Broekema M, Massink M, Donato C, de Ligt J, Schaarschmidt J, Borgman A, et al.
Mol Metab
. 2019 Jan;
20:115-127.
PMID: 30595551
Objective: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-function...
6.
Schaarschmidt J, Monastyrskyy B, Kryshtafovych A, Bonvin A
Proteins
. 2017 Oct;
86 Suppl 1:51-66.
PMID: 29071738
Following up on the encouraging results of residue-residue contact prediction in the CASP11 experiment, we present the analysis of predictions submitted for CASP12. The submissions include predictions of 34 groups...
7.
Moreira I, Koukos P, Melo R, Almeida J, Preto A, Schaarschmidt J, et al.
Sci Rep
. 2017 Aug;
7(1):8007.
PMID: 28808256
We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated accuracy of 0.95 and...
8.
Schaarschmidt J, Nagel M, Huth S, Jaeschke H, Moretti R, Hintze V, et al.
J Biol Chem
. 2016 Apr;
291(27):14095-14108.
PMID: 27129207
The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by binding of the hormone ligand TSH...
9.
Jaeschke H, Schaarschmidt J, Eszlinger M, Huth S, Puttinger R, Rittinger O, et al.
J Clin Endocrinol Metab
. 2014 Jun;
99(10):E2051-9.
PMID: 24947036
Objective: New in vivo mutations in G protein-coupled receptors open opportunities for insights into the mechanism of receptor activation. Here we describe the molecular mechanism of constitutive TSH receptor (TSHR)...