Joerg R Weber
Overview
Explore the profile of Joerg R Weber including associated specialties, affiliations and a list of published articles.
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30
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1389
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Recent Articles
1.
Sharma M, Molina C, Toyoda K, Bereczki D, Bangdiwala S, Kasner S, et al.
Lancet Neurol
. 2023 Dec;
23(1):46-59.
PMID: 38101902
Background: People with factor XI deficiency have lower rates of ischaemic stroke than the general population and infrequent spontaneous bleeding, suggesting that factor XI has a more important role in...
2.
Izadpanah K, Freyer D, Weber J, Braun J
J Neuroimmunol
. 2014 Sep;
276(1-2):104-11.
PMID: 25218213
Triggers of brain inflammation in pneumococcal meningitis are unknown. TNF-α and IL-1β were upregulated (real time PCR and in situ hybridization) in neurons and astrocytes time-dependently and maximally in the...
3.
Reiss A, Braun J, Jager K, Freyer D, Laube G, Buhrer C, et al.
J Infect Dis
. 2010 Dec;
203(3):393-400.
PMID: 21186256
Background: Group B Streptococcus (GBS) and Streptococcus pneumoniae (SP) are leading causes of bacterial meningitis in neonates and children. Each pathogen produces a pore-forming cytolytic toxin, β-hemolysin/cytolysin (β-h/c) by GBS...
4.
Hoffmann O, Zipp F, Weber J
J Mol Med (Berl)
. 2009 May;
87(8):753-63.
PMID: 19449143
In a wide variety of acute and chronic central nervous system (CNS) disorders, inflammatory processes contribute to the damage of brain cells and progression of the disease. Along with other...
5.
Sacha B, Zierler S, Lehnardt S, Weber J, Kerschbaum H
J Neurosci Res
. 2008 Aug;
86(16):3526-35.
PMID: 18709655
Tocopherols (vitamin E) are potent antioxidants as well as modulators of enzymes involved in signal transduction, like nitric oxide synthase (NOS). In primary murine microglial cells and in the microglial...
6.
Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, et al.
J Neurosci
. 2008 Mar;
28(10):2320-31.
PMID: 18322079
Infection, ischemia, trauma, and neoplasia elicit a similar inflammatory response in the CNS characterized by activation of microglia, the resident CNS monocyte. The molecular events leading from CNS injury to...
7.
Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, et al.
J Immunol
. 2007 Oct;
179(9):6134-43.
PMID: 17947688
Microglia, the resident innate immune cells of the CNS, detect invading pathogens via various receptors, including the TLR. Microglia are involved in a number of neurodegenerative diseases in which their...
8.
Lehnardt S, Lehmann S, Kaul D, Tschimmel K, Hoffmann O, Cho S, et al.
J Neuroimmunol
. 2007 Sep;
190(1-2):28-33.
PMID: 17854911
Toll-like receptors (TLR) recognize molecular structures associated with pathogens as well as host-derived components and initiate an inflammatory innate immune response. Microglia represent the resident immune host defense and are...
9.
Hoffmann O, Mahrhofer C, Rueter N, Freyer D, Bert B, Fink H, et al.
Infect Immun
. 2007 Jun;
75(9):4289-97.
PMID: 17591796
Bacterial meningitis is a major infectious cause of neuronal degeneration in the hippocampus. Neurogenesis, a continuous process in the adult hippocampus, could ameliorate such loss. Yet the high rate of...
10.
Hoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N, Lunemann J, et al.
J Clin Invest
. 2007 Jun;
117(7):2004-13.
PMID: 17571163
Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the host immune response. We studied antiinflammatory effects of endogenous and recombinant TRAIL...