Joel M Chick
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Explore the profile of Joel M Chick including associated specialties, affiliations and a list of published articles.
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28
Citations
1451
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Recent Articles
1.
Klebba J, Roy N, Bernard S, Grabow S, Hoffman M, Miao H, et al.
bioRxiv
. 2025 Jan;
PMID: 39763752
Genetic disruption of the RAS binding domain (RBD) of PI 3-kinase (PI3K) prevents the growth of mutant RAS driven tumors in mice and does not impact PI3K's role in insulin...
2.
Li W, Garcia-Rivera E, Mitchell D, Chick J, Maetani M, Knapp J, et al.
bioRxiv
. 2024 Feb;
PMID: 38328167
Ubiquitin is a small, highly conserved protein that acts as a posttranslational modification in eukaryotes. Ubiquitination of proteins frequently serves as a degradation signal, marking them for disposal by the...
3.
Gao X, Wu Y, Chick J, Abbott A, Jiang B, Wang D, et al.
Cell Rep
. 2023 Mar;
42(4):112314.
PMID: 37000627
Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis demonstrates that high CDK6 expression in melanoma is associated with poor...
4.
Kavanagh M, Horning B, Khattri R, Roy N, Lu J, Whitby L, et al.
Nat Chem Biol
. 2022 Sep;
18(11):1288.
PMID: 36180594
No abstract available.
5.
Kavanagh M, Horning B, Khattri R, Roy N, Lu J, Whitby L, et al.
Nat Chem Biol
. 2022 Sep;
18(12):1388-1398.
PMID: 36097295
The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. JAK...
6.
Mirzaei M, Abyadeh M, Turner A, Vander Wall R, Chick J, Paulo J, et al.
Proteomics
. 2022 Jul;
22(19-20):e2100247.
PMID: 35866514
Fingolimod (FTY720) is an oral drug approved by the Food and Drug Administration (FDA) for management of multiple sclerosis (MS) symptoms, which has also shown beneficial effects against Alzheimer's (AD)...
7.
Chick J, Munger S, Simecek P, Huttlin E, Choi K, Gatti D, et al.
Nature
. 2022 Jun;
606(7915):E16.
PMID: 35672473
No abstract available.
8.
Gerdes Gyuricza I, Chick J, Keele G, Deighan A, Munger S, Korstanje R, et al.
Genome Res
. 2022 Mar;
32(5):838-852.
PMID: 35277432
Investigation of the molecular mechanisms of aging in the human heart is challenging because of confounding factors, such as diet and medications, as well as limited access to tissues from...
9.
Takemon Y, Chick J, Gerdes Gyuricza I, Skelly D, Devuyst O, Gygi S, et al.
Elife
. 2021 Mar;
10.
PMID: 33687326
Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels...
10.
Mirzaei M, Gupta V, Chitranshi N, Deng L, Pushpitha K, Abbasi M, et al.
J Cell Biochem
. 2020 Jul;
121(12):4931-4944.
PMID: 32692886
Current evidence suggests that exposure to chronically induced intraocular pressure (IOP) leads to neurodegenerative changes in the inner retina. This study aimed to determine retinal proteomic alterations in a rat...