Edward L Huttlin
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Explore the profile of Edward L Huttlin including associated specialties, affiliations and a list of published articles.
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62
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8336
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Recent Articles
1.
King M, Heger K, Drikic M, Mandwal A, Khan A, Sinasac D, et al.
J Inherit Metab Dis
. 2025 Mar;
48(2):e70018.
PMID: 40033659
The dilated cardiomyopathy with ataxia (DCMA) syndrome is a rare mitochondrial disorder caused by mutations in the poorly understood DNAJC19 gene. Cardiac involvement in DCMA ranges from mild conduction abnormalities...
2.
Gassaway B, Huttlin E, Huntsman E, Yaron-Barir T, Johnson J, Kurmi K, et al.
Mol Cell Proteomics
. 2024 Jun;
23(7):100801.
PMID: 38880243
T cell activation is a complex biological process of naive cells maturing into effector cells. Proteomic and phospho-proteomic approaches have provided critical insights into this process, yet it is not...
3.
Albarnaz J, Kite J, Oliveira M, Li H, Di Y, Christensen M, et al.
Nat Commun
. 2023 Dec;
14(1):8134.
PMID: 38065956
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis...
4.
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
Yiu S, Zerbe C, Vanderwall D, Huttlin E, Weekes M, Gewurz B
Mol Cell
. 2023 Jun;
83(13):2367-2386.e15.
PMID: 37311461
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis, and is associated with 200,000 cancers/year. EBV colonizes the human B cell compartment and periodically reactivates, inducing expression of 80 viral...
5.
Potts M, Fletcher-Etherington A, Nightingale K, Mescia F, Bergamaschi L, Calero-Nieto F, et al.
Cell Rep
. 2023 Jun;
42(6):112613.
PMID: 37302069
Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mechanistic...
6.
Bohmer M, Wang J, Istvan E, Luth M, Collins J, Huttlin E, et al.
ACS Infect Dis
. 2023 Mar;
9(4):1004-1021.
PMID: 36919909
Protein kinases have proven to be a very productive class of therapeutic targets, and over 90 inhibitors are currently in clinical use primarily for the treatment of cancer. Repurposing these...
7.
Geistlinger L, Vargas R, Lee T, Pan J, Huttlin E, Gentleman R
Bioinformatics
. 2023 Feb;
39(3).
PMID: 36794911
Summary: The BioPlex project has created two proteome scale, cell-line-specific protein-protein interaction (PPI) networks: the first in 293T cells, including 120k interactions among 15k proteins; and the second in HCT116...
8.
Yu Q, Liu X, Keller M, Navarrete-Perea J, Zhang T, Fu S, et al.
Nat Commun
. 2023 Feb;
14(1):555.
PMID: 36732331
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay...
9.
Mitchell D, Kuljanin M, Li J, Van Vranken J, Bulloch N, Schweppe D, et al.
Nat Biotechnol
. 2023 Jan;
41(6):845-857.
PMID: 36593396
Defining the cellular response to pharmacological agents is critical for understanding the mechanism of action of small molecule perturbagens. Here, we developed a 96-well-plate-based high-throughput screening infrastructure for quantitative proteomics...
10.
Xiao H, Bozi L, Sun Y, Riley C, Philip V, Chen M, et al.
Cell
. 2022 Nov;
185(24):4654-4673.e28.
PMID: 36334589
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable...