Joel I Perez-Perri
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Explore the profile of Joel I Perez-Perri including associated specialties, affiliations and a list of published articles.
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10
Citations
318
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Recent Articles
1.
Dupont M, Krischuns T, Giai Gianetto Q, Paisant S, Bonazza S, Brault J, et al.
Nucleic Acids Res
. 2024 Apr;
52(12):7188-7210.
PMID: 38686810
Genome-wide approaches have significantly advanced our knowledge of the repertoire of RNA-binding proteins (RBPs) that associate with cellular polyadenylated mRNAs within eukaryotic cells. Recent studies focusing on the RBP interactomes...
2.
Zhou Y, Ray P, Zhu J, Stein F, Rettel M, Sekaran T, et al.
Nat Commun
. 2024 Apr;
15(1):2810.
PMID: 38561347
Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and transcriptomic analyses have demonstrated the exquisite...
3.
Perez-Perri J, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, et al.
Nat Commun
. 2023 Apr;
14(1):2074.
PMID: 37045843
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical...
4.
Huppertz I, Perez-Perri J, Mantas P, Sekaran T, Schwarzl T, Russo F, et al.
Mol Cell
. 2022 Jun;
82(14):2666-2680.e11.
PMID: 35709751
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we report that the catalytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly regulated by RNAs leading...
5.
Perez-Perri J, Noerenberg M, Kamel W, Lenz C, Mohammed S, Hentze M, et al.
Nat Protoc
. 2020 Nov;
16(1):27-60.
PMID: 33208978
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology. However, methods to comprehensively and quantitatively assess these interactions within cells were lacking. RNA interactome capture (RIC) uses...
6.
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri J, Brosig A, et al.
Nucleic Acids Res
. 2020 Apr;
48(9):4725-4740.
PMID: 32313943
Cellular stress causes multifaceted reactions to trigger adaptive responses to environmental cues at all levels of the gene expression pathway. RNA-binding proteins (RBP) are key contributors to stress-induced regulation of...
7.
Perez-Perri J, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, et al.
Nat Commun
. 2018 Oct;
9(1):4408.
PMID: 30352994
Following the realization that eukaryotic RNA-binding proteomes are substantially larger than anticipated, we must now understand their detailed composition and dynamics. Methods such as RNA interactome capture (RIC) have begun...
8.
Perez-Perri J, Dengler V, Audetat K, Pandey A, Bonner E, Urh M, et al.
Cell Rep
. 2016 Jun;
16(1):37-47.
PMID: 27320910
Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene...
9.
Perez-Perri J, Acevedo J, Wappner P
Int J Mol Sci
. 2011 Aug;
12(7):4705-21.
PMID: 21845106
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger...
10.
Dekanty A, Romero N, Bertolin A, Thomas M, Leishman C, Perez-Perri J, et al.
PLoS Genet
. 2010 Jun;
6(6):e1000994.
PMID: 20585616
Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate...