Joel D W Toh
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Explore the profile of Joel D W Toh including associated specialties, affiliations and a list of published articles.
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6
Citations
239
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Recent Articles
1.
Pham V, Bruemmer K, Toh J, Ge E, Tenney L, Ward C, et al.
Science
. 2023 Nov;
382(6670):eabp9201.
PMID: 37917677
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources...
2.
Toh J, Crossley S, Bruemmer K, Ge E, He D, Iovan D, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(41):25284-25292.
PMID: 32989163
The AlkB family of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA). Two major human...
3.
Xie Y, Sun J, Han X, Tursic-Wunder A, Toh J, Hong W, et al.
Nat Commun
. 2019 Nov;
10(1):5078.
PMID: 31699995
A multiprotein complex polarisome nucleates actin cables for polarized cell growth in budding yeast and filamentous fungi. However, the dynamic regulations of polarisome proteins in polymerizing actin under physiological and...
4.
Koh C, Goh Y, Toh J, Neo S, Ng S, Gunaratne J, et al.
Nucleic Acids Res
. 2018 Nov;
46(22):11659-11670.
PMID: 30412255
N6-methyldeoxyadenosine (6mA) is a well-characterized DNA modification in prokaryotes but reports on its presence and function in mammals have been controversial. To address this issue, we established the capacity of...
5.
Toh J, Sun L, Lau L, Tan J, Low J, Tang C, et al.
Chem Sci
. 2017 May;
6(1):112-122.
PMID: 28553460
The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular...
6.
Zou S, Toh J, Wong K, Gao Y, Hong W, Woon E
Sci Rep
. 2016 May;
6:25677.
PMID: 27156733
N(6)-Methyladenosine (m6A) is currently one of the most intensively studied post-transcriptional modifications in RNA. Due to its critical role in epigenetics and physiological links to several human diseases, it is...