Joe R Delaney
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Explore the profile of Joe R Delaney including associated specialties, affiliations and a list of published articles.
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37
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2050
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Recent Articles
11.
Delaney J, La Spada A
STAR Protoc
. 2023 Mar;
4(2):102205.
PMID: 37000621
Translocation sequencing can be used to assess mechanisms of DNA repair and identify genome-wide double-strand breaks (DSBs) accessible to DNA repair machinery. Here, we present a protocol for mapping double-strand...
12.
Liu L, Lin B, Yin S, Ball L, Delaney J, Long D, et al.
Sci Adv
. 2022 Dec;
8(49):eadd8928.
PMID: 36475791
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular...
13.
Helke K, Gudi R, Vasu C, Delaney J
Front Toxicol
. 2022 Jul;
4:937150.
PMID: 35846434
Combination therapy of targeted drugs in cancer treatment is a field in constant flux, with research balancing side effects with efficacy. Efficacy from combination therapy is improved either through synthetic...
14.
Bowers R, Andrade M, Jones C, White-Gilbertson S, Voelkel-Johnson C, Delaney J
BMC Cancer
. 2022 Apr;
22(1):410.
PMID: 35421971
Background: Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of...
15.
Bowers R, Jones C, Paz E, Barrows J, Armeson K, Long D, et al.
Nucleic Acids Res
. 2022 Apr;
50(7):3673-3692.
PMID: 35380699
Haploinsufficiency drives Darwinian evolution. Siblings, while alike in many aspects, differ due to monoallelic differences inherited from each parent. In cancer, solid tumors exhibit aneuploid genetics resulting in hundreds to...
16.
Ko S, Yeom E, Chun Y, Mun H, Howard-McGuire M, Millison N, et al.
J Lipid Atheroscler
. 2022 Feb;
11(1):55-72.
PMID: 35118022
Objective: Glucagon in mammals and its homolog (adipokinetic hormone [AKH] in ) are peptide hormones which regulate lipid metabolism by breaking down triglycerides. Although regulatory mechanisms of glucagon and AKH...
17.
Switonski P, Delaney J, Bartelt L, Niu C, Ramos-Zapatero M, Spann N, et al.
Cell Rep
. 2021 Dec;
37(9):110062.
PMID: 34852229
A common mechanism in inherited ataxia is a vulnerability of DNA damage. Spinocerebellar ataxia type 7 (SCA7) is a CAG-polyglutamine-repeat disorder characterized by cerebellar and retinal degeneration. Polyglutamine-expanded ataxin-7 protein...
18.
Delaney J
Biocell
. 2021 Jul;
45(5):1167-1170.
PMID: 34267416
Single-cell sequencing data has transformed the understanding of biological heterogeneity. While many flavors of single-cell sequencing have been developed, single-cell RNA sequencing (scRNA-seq) is currently the most prolific form in...
19.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
20.
Kumar M, Bowers R, Delaney J
Cell Cycle
. 2020 Oct;
19(22):3154-3166.
PMID: 33121339
Unusually high aneuploidy is a hallmark of epithelial serous ovarian cancer (SOC). Previous analyses have focused on aneuploidy on average across all tumor cells. With the expansion of single-cell sequencing...