Joe A Kaczmarski
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Explore the profile of Joe A Kaczmarski including associated specialties, affiliations and a list of published articles.
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18
Citations
269
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Recent Articles
1.
Kaczmarski J, Jackson C, Cockburn I
Trends Parasitol
. 2025 Feb;
PMID: 39984355
Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding...
2.
Smith O, Frkic R, Rahman M, Jackson C, Kaczmarski J
Biochemistry
. 2024 May;
63(10):1322-1334.
PMID: 38696389
Periplasmic solute-binding proteins (SBPs) are key ligand recognition components of bacterial ATP-binding cassette (ABC) transporters that allow bacteria to import nutrients and metabolic precursors from the environment. Periplasmic SBPs comprise...
3.
Zhang S, Zhang L, Greule A, Tailhades J, Marschall E, Prasongpholchai P, et al.
Acta Pharm Sin B
. 2023 Sep;
13(8):3561-3574.
PMID: 37655329
WS9326A is a peptide antibiotic containing a highly unusual -methyl--2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by (P450)...
4.
Ho Y, Kaczmarski J, Tailhades J, Izore T, Steer D, Schittenhelm R, et al.
Chem Commun (Camb)
. 2023 Jun;
59(53):8234-8237.
PMID: 37310188
Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains. We show that the replacement of CP...
5.
East N, Clifton B, Jackson C, Kaczmarski J
Protein Sci
. 2022 Nov;
31(12):e4510.
PMID: 36382881
The emergence of oligomers is common during the evolution and diversification of protein families, yet the selective advantage of oligomerization is often cryptic or unclear. Oligomerization can involve the formation...
6.
Joho Y, Vongsouthi V, Spence M, Ton J, Gomez C, Tan L, et al.
Biochemistry
. 2022 Aug;
62(2):437-450.
PMID: 35951410
The improved production, recycling, and removal of plastic waste, such as polyethylene terephthalate (PET), are pressing environmental and economic issues for society. Biocatalytic (enzymatic) PET depolymerization is potentially a sustainable,...
7.
Ayva C, Fiorito M, Guo Z, Edwardraja S, Kaczmarski J, Gagoski D, et al.
J Mol Biol
. 2022 Jun;
434(17):167678.
PMID: 35709893
Biological information processing networks rely on allosteric protein switches that dynamically interconvert biological signals. Construction of their artificial analogues is a central goal of synthetic biology and bioengineering. Receptor domain...
8.
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
Ford D, Duggan N, Fry S, Ripoll-Rozada J, Agten S, Liu W, et al.
J Med Chem
. 2021 May;
64(11):7853-7876.
PMID: 34044534
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa),...
9.
Spence M, Kaczmarski J, Saunders J, Jackson C
Curr Opin Struct Biol
. 2021 May;
69:131-141.
PMID: 34023793
In addition to its value in the study of molecular evolution, ancestral sequence reconstruction (ASR) has emerged as a useful methodology for engineering proteins with enhanced properties. Proteins generated by...
10.
Izore T, Ho Y, Kaczmarski J, Gavriilidou A, Chow K, Steer D, et al.
Nat Commun
. 2021 May;
12(1):2511.
PMID: 33947858
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by...