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JodiAnne Wood

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Articles 9
Citations 110
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Recent Articles
1.
Malamas M, Lamani M, Farah S, Mohammad K, Miyabe C, Rajarshi G, et al.
ChemMedChem . 2021 Sep; 18(21):e202100406. PMID: 34486233
Fine-tuning than complete disruption of 2-arachidonoylglycerol (2-AG) metabolism in the brain represents a promising pharmacological approach to limit potential untoward effects associated with complete blockade of monoacylglycerol lipase (MGL), the...
2.
Honrao C, Ma X, Kulkarni S, Joshi V, Malamas M, Zvonok A, et al.
Front Pharmacol . 2021 May; 12:630274. PMID: 33967764
[This corrects the article DOI: 10.3389/fphar.2020.575691.].
3.
Honrao C, Ma X, Kulkarni S, Joshi V, Malamas M, Zvonok A, et al.
Front Pharmacol . 2020 Oct; 11:575691. PMID: 33101030
Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly...
4.
Alapafuja S, Malamas M, Shukla V, Zvonok A, Miller S, Daily L, et al.
Bioorg Med Chem . 2018 Nov; 27(1):55-64. PMID: 30446439
Monoacylglycerol lipase (MGL) inhibition provides a potential treatment approach to glaucoma through the regulation of ocular 2-arachidonoylglycerol (2-AG) levels and the activation of CB1 receptors. Herein, we report the discovery...
5.
Weltrowska G, Nguyen T, Chung N, Wood J, Ma X, Guo J, et al.
J Med Chem . 2016 Sep; 59(19):9243-9254. PMID: 27676089
Head-to-tail cyclization of the μ opioid receptor (MOR) agonist [Dmt]DALDA (H-Dmt-d-Arg-Phe-Lys-NH (9; Dmt = 2',6'-dimethyltyrosine) resulted in a highly active, selective MOR antagonist, c[-d-Arg-Phe-Lys-Dmt-] (1) ("cyclodal"), with subnanomolar binding affinity....
6.
Jarbe T, LeMay B, Halikhedkar A, Wood J, Vadivel S, Zvonok A, et al.
Psychopharmacology (Berl) . 2013 Sep; 231(3):489-500. PMID: 24005529
Rationale: The "subjective high" from marijuana ingestion is likely due to Δ(9)-tetrahydrocannabinol (THC) activating the central cannabinoid receptor type 1 (CB1R) of the endocannabinoid signaling system. THC is a weak...
7.
Jiang S, Fu Y, Williams J, Wood J, Pandarinathan L, Avraham S, et al.
PLoS One . 2007 Jul; 2(7):e641. PMID: 17653268
Background: Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate. ES cells differentiate into multiple hematopoietic...
8.
Williams J, Wood J, Pandarinathan L, Karanian D, Bahr B, Vouros P, et al.
Anal Chem . 2007 Jun; 79(15):5582-93. PMID: 17600384
The endocannabinoid system's biological significance continues to grow as novel endocannabinoid metabolites are discovered. Accordingly, a myopic view of the system that focuses solely on one or two endocannabinoids, such...
9.
Williams J, Pandarinathan L, Wood J, Vouros P, Makriyannis A
AAPS J . 2007 Jan; 8(4):E655-60. PMID: 17233529
We have synthesized 4,4-dimethoxyoxazoline derivatives of several fatty acids associated with the endocannabinoid metabolome using tris(hydroxymethyl)aminomethane in a 1-step reaction by microwave irradiation. The derivatization incorporates a nitrogen into the...