Jochen S Hub
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Explore the profile of Jochen S Hub including associated specialties, affiliations and a list of published articles.
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91
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2620
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Recent Articles
31.
Macosek J, Simon B, Linse J, Jagtap P, Winter S, Foot J, et al.
Nucleic Acids Res
. 2021 Jul;
49(15):8866-8885.
PMID: 34329466
A key regulatory process during Drosophila development is the localized suppression of the hunchback mRNA translation at the posterior, which gives rise to a hunchback gradient governing the formation of...
32.
Linse J, Hub J
J Chem Phys
. 2021 Jul;
154(19):194501.
PMID: 34240910
Heavy water or deuterium oxide, DO, is used as a solvent in various biophysical and chemical experiments. To model such experiments with molecular dynamics simulations, effective pair potentials for heavy...
33.
Anselmi M, Hub J
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33888588
The Src-homology-2 domain-containing phosphatase SHP2 is a critical regulator of signal transduction, being implicated in cell growth and differentiation. Activating mutations cause developmental disorders and act as oncogenic drivers in...
34.
Hamann F, Zimmerningkat L, Becker R, Garbers T, Neumann P, Hub J, et al.
Acta Crystallogr D Struct Biol
. 2021 Apr;
77(Pt 4):496-509.
PMID: 33825710
Noncoding intron sequences present in precursor mRNAs need to be removed prior to translation, and they are excised via the spliceosome, a multimegadalton molecular machine composed of numerous protein and...
35.
Verbeek S, Awasthi N, Teiwes N, Mey I, Hub J, Janshoff A
Eur Biophys J
. 2021 Mar;
50(2):127-142.
PMID: 33661339
Arginine (R)-rich peptides constitute the most relevant class of cell-penetrating peptides and other membrane-active peptides that can translocate across the cell membrane or generate defects in lipid bilayers such as...
36.
Hermann M, Hub J
Methods Mol Biol
. 2021 Feb;
2168:199-215.
PMID: 33582993
Small- and wide-angle X-ray scattering (SAXS/WAXS/SWAXS) have evolved to be accurate tools used to gain structural information of biomolecules in solution. However, the interpretation of SWAXS data remains challenging owing...
37.
Hub J
J Chem Theory Comput
. 2021 Jan;
17(2):1229-1239.
PMID: 33427469
Topological transitions of membranes, such as pore formation or membrane fusion, play key roles in biology, biotechnology, and in medical applications. Calculating the related free-energy landscapes has been complicated by...
38.
Awasthi N, Kopec W, Wilkosz N, Jamroz D, Hub J, Zatorska M, et al.
ACS Biomater Sci Eng
. 2021 Jan;
5(2):780-794.
PMID: 33405839
Polycations are an attractive class of macromolecules with promising applications as drug/gene carriers and biocides. The chemical structure and concentration of a polycation determine its interaction with cellular membranes and,...
39.
Panman M, Biasin E, Berntsson O, Hermann M, Niebling S, Hughes A, et al.
Phys Rev Lett
. 2020 Dec;
125(22):226001.
PMID: 33315438
Resolving the structural dynamics of the initial steps of chemical reactions is challenging. We report the femtosecond time-resolved wide-angle x-ray scattering of the photodissociation of diiodomethane in cyclohexane. The data...
40.
Anselmi M, Hub J
Sci Rep
. 2020 Oct;
10(1):18530.
PMID: 33116231
SHP2 is a protein tyrosine phosphatase (PTP) involved in multiple signaling pathways. Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of wild-type SHP2 represents a novel...