Joaquim Ros
Overview
Explore the profile of Joaquim Ros including associated specialties, affiliations and a list of published articles.
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51
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1382
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Recent Articles
11.
Britti E, Delaspre F, Tamarit J, Ros J
Neuronal Signal
. 2020 Jul;
2(4):NS20180061.
PMID: 32714593
Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute...
12.
Purroy R, Medina-Carbonero M, Ros J, Tamarit J
Redox Biol
. 2020 Apr;
32:101520.
PMID: 32279039
Friedreich ataxia (FA) is a cardioneurodegenerative disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Previously, we set up...
13.
Britti E, Delaspre F, Tamarit J, Ros J
Neurochem Res
. 2020 Apr;
46(1):108-119.
PMID: 32249386
Calpains are calcium-dependent proteases activated in apoptotic cell death and neurodegeneration. Friedreich Ataxia is a neurodegenerative rare disease caused by frataxin deficiency, a mitochondrial protein. Dorsal root ganglion (DRG) sensory...
14.
Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death
Britti E, Ros J, Esteras N, Abramov A
Cell Calcium
. 2020 Jan;
86:102150.
PMID: 31918031
Aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, Alzheimer's disease; or frontotemporal...
15.
Alsina D, Purroy R, Ros J, Tamarit J
Pharmaceuticals (Basel)
. 2018 Sep;
11(3).
PMID: 30235822
Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of...
16.
Fernandez-Fernandez S, Bobo-Jimenez V, Requejo-Aguilar R, Gonzalez-Fernandez S, Resch M, Carabias-Carrasco M, et al.
Redox Biol
. 2018 Aug;
19:52-61.
PMID: 30107295
Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been...
17.
Jimenez-Altayo F, Meirelles T, Crosas-Molist E, Sorolla M, Gorbenko Del Blanco D, Lopez-Luque J, et al.
Free Radic Biol Med
. 2018 Feb;
118:44-58.
PMID: 29471108
Marfan syndrome (MFS) is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix fibrillin-containing microfibrils and dysfunction of TGF-β signaling. Here we identify the...
18.
Britti E, Delaspre F, Feldman A, Osborne M, Greif H, Tamarit J, et al.
J Cell Mol Med
. 2017 Oct;
22(2):834-848.
PMID: 28980774
Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to...
19.
Alsina D, Ros J, Tamarit J
Redox Biol
. 2017 Sep;
14:131-141.
PMID: 28918000
Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast...
20.
Tamarit J, Obis E, Ros J
Free Radic Biol Med
. 2016 Jun;
100:138-146.
PMID: 27296838
Friedreich ataxia is a genetic disease caused by the deficiency of frataxin, a mitochondrial protein. Frataxin deficiency impacts in the cell physiology at several levels. One of them is oxidative...