Joanna Klapacz
Overview
Explore the profile of Joanna Klapacz including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
335
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Recent Articles
1.
Lafranconi M, Anderson J, Budinsky R, Corey L, Forsberg N, Klapacz J, et al.
Regul Toxicol Pharmacol
. 2023 Jun;
142:105428.
PMID: 37277058
1,4-Dioxane is an environmental contaminant that has been shown to cause cancer in rodents after chronic high dose exposures. We reviewed and integrated information from recently published studies to update...
2.
Kozal J, Lynch H, Klapacz J, Schoeny R, Jean P, Maier A
Chem Biol Interact
. 2023 Feb;
382:110382.
PMID: 36754223
As part of a systematic review of the non-cancer and cancer hazards of propylene dichloride (PDC), with a focus on potential carcinogenicity in workers following inhalation exposures, we determined that...
3.
Lafranconi M, Budinsky R, Corey L, Klapacz J, Crissman J, LeBaron M, et al.
Regul Toxicol Pharmacol
. 2020 Nov;
119:104819.
PMID: 33189748
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns with a threshold-dependent, tumor promotion mode of action (MOA)....
4.
Klapacz J, Gollapudi B
Environ Mol Mutagen
. 2019 Jul;
61(1):84-93.
PMID: 31301246
Assessment of a chemical's potential to cause permanent changes in the genetic code has been a common practice in the industry and regulatory settings for decades. Furthermore, the genetic toxicity...
5.
Zhang F, Erskine T, Klapacz J, Settivari R, Marty S
J Pharmacol Toxicol Methods
. 2018 Aug;
94(Pt 2):1-15.
PMID: 30099091
While the HPLC/UV (high performance liquid chromatography coupled with ultra-violet spectrometry)-based DPRA (Direct Peptide Reactivity Assay) identifies dermal sensitizers with approximately 80% accuracy, the low selectivity and sensitivity of the...
6.
Fowles J, Banton M, Klapacz J, Shen H
Toxicol Lett
. 2017 Jul;
278:66-83.
PMID: 28689762
This review summarizes the hazards, exposure and risk that are associated with ethylene glycols (EGs) in their intended applications. Ethylene glycol (EG; CAS RN 107-21-1) and its related oligomers include...
7.
Snellings W, McMartin K, Banton M, Reitman F, Klapacz J
Regul Toxicol Pharmacol
. 2017 May;
87 Suppl 2:S1-S20.
PMID: 28465071
Diethylene glycol (DEG) is an organic chemical that is used mostly as a chemical intermediate and has minor uses as a solvent or antifreeze in consumer products; these minor uses...
8.
Klapacz J, Pottenger L, Engelward B, Heinen C, Johnson G, Clewell R, et al.
Mutat Res Rev Mutat Res
. 2016 Apr;
767:77-91.
PMID: 27036068
From a risk assessment perspective, DNA-reactive agents are conventionally assumed to have genotoxic risks at all exposure levels, thus applying a linear extrapolation for low-dose responses. New approaches discussed here,...
9.
Meira L, Calvo J, Shah D, Klapacz J, Moroski-Erkul C, Bronson R, et al.
DNA Repair (Amst)
. 2014 Jul;
21:78-86.
PMID: 24994062
The accumulation of DNA damage is thought to contribute to the physiological decay associated with the aging process. Here, we report the results of a large-scale study examining longevity in...
10.
West R, Banton M, Hu J, Klapacz J
Rev Environ Contam Toxicol
. 2014 Jul;
232:107-38.
PMID: 24984837
The propylene glycol substances comprise a homologous family of synthetic organic molecules that have widespread use and very high production volumes across the globe. The information presented and summarized here...