Joan M Boylan
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Explore the profile of Joan M Boylan including associated specialties, affiliations and a list of published articles.
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21
Citations
258
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Recent Articles
1.
Ohman A, Raigani S, Santiago J, Heaney M, Boylan J, Parry N, et al.
Am J Physiol Gastrointest Liver Physiol
. 2021 Nov;
322(1):G21-G33.
PMID: 34730028
Liver transplantation is hampered by a severe shortage of donor organs. Normothermic machine perfusion (NMP) of donor livers allows dynamic preservation in addition to viability assessment before transplantation. Little is...
2.
Santiago J, Boylan J, Lemieux F, Gruppuso P, Sanders J, Rand D
BMC Genomics
. 2021 Mar;
22(1):213.
PMID: 33761878
Background: In addition to their well characterized role in cellular energy production, new evidence has revealed the involvement of mitochondria in diverse signaling pathways that regulate a broad array of...
3.
Zabala V, Boylan J, Thevenot P, Frank A, Senthoor D, Iyengar V, et al.
PLoS One
. 2020 Jan;
14(12):e0227038.
PMID: 31891620
There are few effective targeted strategies to reduce hepatic ischemia-reperfusion (IR) injury, a contributor to poor outcomes in liver transplantation recipients. It has been proposed that IR injury is driven...
4.
Gruppuso P, Boylan J, Zabala V, Neretti N, Abshiru N, Sikora J, et al.
PLoS One
. 2018 Sep;
13(9):e0203351.
PMID: 30192817
Chromatin structure, a key contributor to the regulation of gene expression, is modulated by a broad array of histone post-translational modifications (PTMs). Taken together, these "histone marks" comprise what is...
5.
Hurley E, Zabala V, Boylan J, Gruppuso P, Sanders J
Gene Expr
. 2018 Jun;
19(1):1-13.
PMID: 29929573
During the immediate postnatal (PN) period, the liver, with its role in energy metabolism and macromolecule synthesis, plays a central role in the perinatal transition. Using RNA microarrays and several...
6.
Boylan J, Francois-Vaughan H, Gruppuso P, Sanders J
Transplantation
. 2017 Jul;
101(10):2349-2359.
PMID: 28749819
Background: The limited availability of donor organs has led to a search for alternatives to liver transplantation to restore liver function and bridge patients to transplantation. We have shown that...
7.
Boylan J, Sanders J, Gruppuso P
Am J Physiol Regul Integr Comp Physiol
. 2016 Jul;
311(3):R478-88.
PMID: 27357801
Limited nutrient availability is a cause of intrauterine growth restriction (IUGR), a condition that has important implications for the well being of the offspring. Using the established IUGR model of...
8.
Boylan J, Salomon A, Tantravahi U, Gruppuso P
Exp Cell Res
. 2015 May;
335(2):224-37.
PMID: 25999147
Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we...
9.
Boylan J, Sanders J, Neretti N, Gruppuso P
Am J Physiol Regul Integr Comp Physiol
. 2015 May;
309(1):R22-35.
PMID: 25924882
The mechanistic target of rapamycin (mTOR) integrates growth factor signaling, nutrient abundance, cell growth, and proliferation. On the basis of our interest in somatic growth in the late gestation fetus,...
10.
Lamming D, Demirkan G, Boylan J, Mihaylova M, Peng T, Ferreira J, et al.
FASEB J
. 2013 Sep;
28(1):300-15.
PMID: 24072782
The mechanistic target of rapamycin (mTOR) exists in two complexes that regulate diverse cellular processes. mTOR complex 1 (mTORC1), the canonical target of rapamycin, has been well studied, whereas the...