Joan B Broderick
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Explore the profile of Joan B Broderick including associated specialties, affiliations and a list of published articles.
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97
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Recent Articles
1.
Vagstad A, Vagstad A, Lakis E, Csizi K, Walls W, Richter D, et al.
Angew Chem Int Ed Engl
. 2024 Dec;
64(6):e202418054.
PMID: 39688170
Radical S-adenosyl methionine enzymes catalyze a diverse repertoire of post-translational modifications in protein and peptide substrates. Among these, an exceptional and mechanistically obscure example is the installation of α-keto-β-amino acid...
2.
Fu B, Yang H, Kountz D, Lundahl M, Beller H, Broderick W, et al.
J Am Chem Soc
. 2024 Oct;
146(43):29645-29655.
PMID: 39392720
Radical enzymes, including the evolutionarily ancient glycyl radical enzyme (GRE) family, catalyze chemically challenging reactions that are involved in a myriad of important biological processes. All GREs possess an essential,...
3.
Pagnier A, Balci B, Shepard E, Yang H, Drena A, Holliday G, et al.
J Biol Chem
. 2024 Sep;
300(10):107760.
PMID: 39260698
The generation of an active [FeFe]-hydrogenase requires the synthesis of a complex metal center, the H-cluster, by three dedicated maturases: the radical S-adenosyl-l-methionine (SAM) enzymes HydE and HydG, and the...
4.
Walls W, Vagstad A, Delridge T, Piel J, Broderick W, Broderick J
J Am Chem Soc
. 2024 Feb;
146(8):5550-5559.
PMID: 38364824
OspD is a radical -adenosyl-l-methionine (SAM) peptide epimerase that converts an isoleucine (Ile) and valine (Val) of the OspA substrate to d-amino acids during biosynthesis of the ribosomally synthesized and...
5.
Yang H, Ho M, Lundahl M, Mosquera M, Broderick W, Broderick J, et al.
J Am Chem Soc
. 2024 Feb;
146(6):3710-3720.
PMID: 38308759
H and C hyperfine coupling constants to 5'-deoxyadenosyl (5'-dAdo•) radical trapped within the active site of the radical -adenosyl-l-methionine (SAM) enzyme, pyruvate formate lyase-activating enzyme (PFL-AE), both in the absence...
6.
Fausset H, Spietz R, Cox S, Cooper G, Spurzem S, Tokmina-Lukaszewska M, et al.
Microbiol Spectr
. 2024 Jan;
12(2):e0041823.
PMID: 38179920
Iron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of microorganisms. In anoxic environments, soluble Fe typically...
7.
Lundahl M, Yang H, Broderick W, Hoffman B, Broderick J
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2314696120.
PMID: 37956301
Enzymes of the radical -adenosyl-l-methionine (radical SAM, RS) superfamily, the largest in nature, catalyze remarkably diverse reactions initiated by H-atom abstraction. Glycyl radical enzyme activating enzymes (GRE-AEs) are a growing...
8.
Balci B, ONeill R, Shepard E, Pagnier A, Marlott A, Mock M, et al.
Chem Commun (Camb)
. 2023 Jun;
59(58):8929-8932.
PMID: 37376915
Here we describe maturation of the [FeFe]-hydrogenase from its [4Fe-4S]-bound precursor state by using the synthetic complex [Fe(μ-SH)(CN)(CO)] together with HydF and components of the glycine cleavage system, but in...
9.
Jodts R, Wittkop M, Ho M, Broderick W, Broderick J, Hoffman B, et al.
J Am Chem Soc
. 2023 Jun;
145(25):13879-13887.
PMID: 37307050
The radical -adenosyl methionine (SAM) enzyme superfamily has widespread roles in hydrogen atom abstraction reactions of crucial biological importance. In these enzymes, reductive cleavage of SAM bound to a [4Fe-4S]...
10.
Moody J, Hill S, Lundahl M, Saxton A, Galambas A, Broderick W, et al.
J Biol Chem
. 2023 May;
299(6):104791.
PMID: 37156396
Radical S-adenosyl-l-methionine (SAM) enzymes are ubiquitous in nature and carry out a broad variety of difficult chemical transformations initiated by hydrogen atom abstraction. Although numerous radical SAM (RS) enzymes have...