Joachim W Deitmer
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Explore the profile of Joachim W Deitmer including associated specialties, affiliations and a list of published articles.
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99
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2209
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Recent Articles
1.
Becker H, Deitmer J
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33804674
Intra- and extracellular pH regulation is a pivotal function of all cells and tissues. Net outward transport of H is a prerequisite for normal physiological function, since a number of...
2.
Duscha K, Rodrigues C, Muller M, Wartenberg R, Fliegel L, Deitmer J, et al.
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32397251
The plasma membrane transporter SOS1 (SALT-OVERLY SENSITIVE1) is vital for plant survival under salt stress. SOS1 activity is tightly regulated, but little is known about the underlying mechanism. SOS1 contains...
3.
Becker H, Deitmer J
Cancers (Basel)
. 2020 Apr;
12(4).
PMID: 32272695
Solid tumors are metabolically highly active tissues, which produce large amounts of acid. The acid/base balance in tumor cells is regulated by the concerted interplay between a variety of membrane...
4.
Deitmer J, Theparambil S, Ruminot I, Noor S, Becker H
Front Neurosci
. 2019 Dec;
13:1301.
PMID: 31866811
Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to...
5.
Khakipoor S, Giannaki M, Theparambil S, Zecha J, Kuster B, Heermann S, et al.
Glia
. 2019 Jul;
67(12):2264-2278.
PMID: 31318482
The electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), is the major bicarbonate transporter expressed in astrocytes. It is highly sensitive for bicarbonate and the main regulator of intracellular, extracellular, and...
6.
Aspatwar A, Tolvanen M, Schneider H, Becker H, Narkilahti S, Parkkila S, et al.
FEBS Open Bio
. 2019 Apr;
9(7):1204-1211.
PMID: 31033227
Carbonic anhydrases (CA) catalyze the reversible hydration of CO to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption...
7.
Hiremath S, Surulescu C, Jamali S, Ames S, Deitmer J, Becker H
Math Biosci Eng
. 2019 Jan;
16(1):320-337.
PMID: 30674122
The most aggressive tumor cells, which often reside in a hypoxic environment, can release vast amounts of lactate and protons via monocarboxylate transporters (MCTs). This additional proton efflux exacerbates extracellular...
8.
Forero-Quintero L, Ames S, Schneider H, Thyssen A, Boone C, Andring J, et al.
J Biol Chem
. 2018 Nov;
294(2):593-607.
PMID: 30446621
Monocarboxylate transporters (MCTs) mediate the proton-coupled exchange of high-energy metabolites, including lactate and pyruvate, between cells and tissues. The transport activity of MCT1, MCT2, and MCT4 can be facilitated by...
9.
Noor Z, Deitmer J, Theparambil S
J Cell Physiol
. 2018 Aug;
234(1):89-99.
PMID: 30132845
Sodium plays a major role in different astrocytic functions, including maintenance of ion homeostasis and uptake of neurotransmitters and metabolites, which are mediated by different Na -coupled transporters. In the...
10.
Noor S, Jamali S, Ames S, Langer S, Deitmer J, Becker H
Elife
. 2018 May;
7.
PMID: 29809145
Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of metabolism. In the present study,...