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Joachim E Schultz

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Articles 58
Citations 1273
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Recent Articles
1.
Landau M, Elsabbagh S, Gross H, Fuchs A, Schultz A, Schultz J
Elife . 2024 Nov; 13. PMID: 39611663
The biosynthesis of cyclic 3',5'-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs). Up to now the two hexahelical transmembrane domains of mACs...
2.
Elsabbagh S, Landau M, Gross H, Schultz A, Schultz J
Cell Signal . 2022 Dec; 103:110568. PMID: 36565898
Acidic lipid extracts from mouse liver, kidney, heart, brain, and lung inhibited human pseudoheterodimeric adenylyl cyclases (hACs) expressed in HEK293 cells. Using an acidic lipid extract from bovine lung, a...
3.
Schultz J
Front Pharmacol . 2022 Oct; 13:1009797. PMID: 36238545
The nine membrane-delimited eukaryotic adenylyl cyclases are pseudoheterodimers with an identical domain order of seven (nine) distinct subdomains. Bioinformatics show that the protein evolved from a monomeric bacterial progenitor by...
4.
Seth A, Landau M, Shevchenko A, Traikov S, Schultz A, Elsabbagh S, et al.
Cell Signal . 2022 Jul; 97:110396. PMID: 35787445
Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical membrane domains, which are isoform-specifically conserved. Previously we proposed that these membrane domains are orphan receptors (https://doi.org/10.7554/eLife.13098; https://doi.org/10.1016/j.cellsig.2020.109538). Lipids extracted...
5.
Beltz S, Schultz J
Bio Protoc . 2021 Aug; 7(2):e2112. PMID: 34458439
The direct regulation of a mycobacterial adenylate cyclase (Rv1625c) via exchange of its membrane anchor by the quorum sensing receptor CqsS () has recently been reported ( Beltz , 2016...
6.
Seth A, Finkbeiner M, Grischin J, Schultz J
Cell Signal . 2020 Jan; 68:109538. PMID: 31931092
Mammalian adenylate cyclases (ACs) are pseudoheterodimers with dissimilar hexahelical membrane-anchors, isoform-specifically conserved for more than half a billion years. We exchanged both membrane anchors of the AC isoform 2 by...
7.
Finkbeiner M, Grischin J, Seth A, Schultz J
Int J Med Microbiol . 2019 Apr; 309(3-4):245-251. PMID: 30954381
Nine pseudoheterodimeric mammalian adenylate cyclases possess two dissimilar hexahelical membrane domains (TM1 and TM2), two dissimilar cyclase-transducing-elements (CTEs) and two complementary catalytic domains forming a catalytic dimer (often termed cyclase-homology-domain,...
8.
Wissig J, Grischin J, Bassler J, Schubert C, Friedrich T, Bahre H, et al.
Mol Microbiol . 2019 Mar; 112(1):16-28. PMID: 30901498
The nucleotide cyclase CyaC of Sinorhizobium meliloti is a member of class III adenylate cyclases (AC), a diverse group present in all forms of life. CyaC is membrane-integral by a...
9.
Bassler J, Schultz J, Lupas A
Cell Signal . 2018 Mar; 46:135-144. PMID: 29563061
Class III adenylate cyclases (ACs) are widespread signaling proteins, which translate diverse intracellular and extracellular stimuli into a uniform intracellular signal. They are typically composed of an N-terminal array of...
10.
Ziegler M, Bassler J, Beltz S, Schultz A, Lupas A, Schultz J
FEBS J . 2017 Feb; 284(8):1204-1217. PMID: 28222489
Adenylate cyclases (ACs) are signaling proteins that produce the second messenger cAMP. Class III ACs comprise four groups (class IIIa-d) of which class IIIa and IIIb ACs have been identified...