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Jo Demeester

Explore the profile of Jo Demeester including associated specialties, affiliations and a list of published articles. Areas
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Articles 73
Citations 1459
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Recent Articles
1.
Xiong R, Verstraelen P, Demeester J, Skirtach A, Timmermans J, De Smedt S, et al.
Front Cell Neurosci . 2018 Apr; 12:80. PMID: 29651235
Neurodevelopmental and neurodegenerative disorders are characterized by subtle alterations in synaptic connections and perturbed neuronal network functionality. A hallmark of neuronal connectivity is the presence of dendritic spines, micron-sized protrusions...
2.
Zagato E, Brans T, Verstuyft S, Van Thourhout D, Missinne J, Van Steenberge G, et al.
Opt Express . 2018 Mar; 25(3):1732-1745. PMID: 29519027
Light sheet microscopy is a relatively new form of fluorescence microscopy that has been receiving a lot of attention recently. The strong points of the technique, such as high signal...
3.
Vermeulen L, Brans T, Samal S, Dubruel P, Demeester J, De Smedt S, et al.
ACS Nano . 2018 Mar; 12(3):2332-2345. PMID: 29505236
In gene therapy, endosomal escape represents a major bottleneck since nanoparticles often remain entrapped inside endosomes and are trafficked toward the lysosomes for degradation. A detailed understanding of the endosomal...
4.
Zagato E, Vermeulen L, Dewitte H, Van Imschoot G, Vandenbroucke R, Demeester J, et al.
Mol Pharm . 2018 Feb; 15(3):1142-1149. PMID: 29433310
Nucleic acid biopharmaceuticals are being investigated as potential therapeutics. They need to be incorporated into a biocompatible carrier so as to overcome several biological barriers. Rational development of suitable nanocarriers...
5.
Xiong R, Drullion C, Verstraelen P, Demeester J, Skirtach A, Abbadie C, et al.
J Control Release . 2017 Oct; 266:198-204. PMID: 28965859
Intracellular delivery of functional compounds into living cells is of great importance for cell biology as well as therapeutic applications. Often it is sufficient that the compound of interest (being...
6.
Manshian B, Martens T, Kantner K, Braeckmans K, De Smedt S, Demeester J, et al.
J Nanobiotechnology . 2017 Jun; 15(1):45. PMID: 28619032
Background: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for...
7.
Martens T, Peynshaert K, Leite Nascimento T, Fattal E, Karlstetter M, Langmann T, et al.
Eur J Pharm Sci . 2017 Feb; 103:27-35. PMID: 28223236
Intravitreal administration of nanomedicines could be valuable for retinal gene therapy, if their mobility in the vitreous and therapeutic efficacy in the target cells can be guaranteed. Hyaluronic acid (HA)...
8.
Xiong R, Joris F, Liang S, De Rycke R, Lippens S, Demeester J, et al.
Nano Lett . 2016 Sep; 16(10):5975-5986. PMID: 27684962
Long-term in vivo imaging of cells is crucial for the understanding of cellular fate in biological processes in cancer research, immunology, or in cell-based therapies such as beta cell transplantation...
9.
Xiong R, Vandenbroucke R, Broos K, Brans T, Van Wonterghem E, Libert C, et al.
Nat Commun . 2016 Sep; 7:12982. PMID: 27653841
Sizing nanomaterials in complex biological fluids, such as blood, remains a great challenge in spite of its importance for a wide range of biomedical applications. In drug delivery, for instance,...
10.
Wayteck L, Dewitte H, De Backer L, Breckpot K, Demeester J, De Smedt S, et al.
Biomaterials . 2015 Nov; 77:243-54. PMID: 26606450
Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of...