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Jiusheng Lin

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Articles 18
Citations 366
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Recent Articles
1.
Jones J, Lin J, Sharmeen S, Rahman M, Truong H, Chern T, et al.
Anal Chim Acta . 2025 Jan; 1336:343520. PMID: 39788673
Background: DJ-1 is a protein whose mutation causes rare heritable forms of Parkinson's disease (PD) and is of interest as a target for treating PD and other disorders. This work...
2.
Dupuy E, Van der Verren S, Lin J, Wilson M, Dachsbeck A, Viela F, et al.
Cell . 2023 Feb; 186(5):1039-1049.e17. PMID: 36764293
Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial questions...
3.
Li Y, Wang T, Wan Q, Wang Q, Chen Z, Gao Y, et al.
Cancer Res . 2022 Jul; 82(19):3573-3587. PMID: 35895752
Significance: The identification of a TRAF4/Caveolin-1 axis that plays a crucial role in malignant progression of glioblastoma provides new insights into the function of TRAF4 in ubiquitin signaling and suggests...
4.
Haas D, Thamm A, Sun J, Huang L, Sun L, Beaudoin G, et al.
mBio . 2022 Jul; 13(4):e0163022. PMID: 35862786
Analysis of the genes retained in the minimized JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions...
5.
Mazza M, Shuck S, Lin J, Moxley M, Termini J, Cookson M, et al.
J Neurochem . 2022 Jun; 162(3):245-261. PMID: 35713360
Human DJ-1 is a cytoprotective protein whose absence causes Parkinson's disease and is also associated with other diseases. DJ-1 has an established role as a redox-regulated protein that defends against...
6.
Prahlad J, Yuan Y, Lin J, Chang C, Iwata-Reuyl D, Liu Y, et al.
J Biol Chem . 2020 Aug; 295(41):14236-14247. PMID: 32796037
DUF328 family proteins are present in many prokaryotes; however, their molecular activities are unknown. The DUF328 protein YaaA is a member of the OxyR regulon and is protective against oxidative...
7.
Bahmed K, Boukhenouna S, Karim L, Andrews T, Lin J, Powers R, et al.
Cell Death Dis . 2019 Sep; 10(9):638. PMID: 31474749
DJ-1 is a multifunctional protein with cytoprotective functions. It is localized in the cytoplasm, nucleus, and mitochondria. The conserved cysteine residue at position 106 (Cys106) within DJ-1 serves as a...
8.
Catazaro J, Andrews T, Milkovic N, Lin J, Lowe A, Wilson M, et al.
Anal Biochem . 2017 Nov; 542:24-28. PMID: 29169778
Previous studies have shown that relaxation parameters and fast protein dynamics can be quickly elucidated from N-CEST experiments [1]. Longitudinal R and transverse R values were reliably derived from fitting...
9.
Lin J, Pozharski E, Wilson M
Biochemistry . 2016 Dec; 56(2):391-402. PMID: 27989121
Short hydrogen bonds (H-bonds) have been proposed to play key functional roles in several proteins. The location of the proton in short H-bonds is of central importance, as proton delocalization...
10.
Lin J, van den Bedem H, Brunger A, Wilson M
Acta Crystallogr D Struct Biol . 2016 Feb; 72(Pt 1):83-92. PMID: 26894537
Calmodulin (CaM) is the primary calcium signaling protein in eukaryotes and has been extensively studied using various biophysical techniques. Prior crystal structures have noted the presence of ambiguous electron density...