Jiun-Sheng Chen
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Explore the profile of Jiun-Sheng Chen including associated specialties, affiliations and a list of published articles.
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21
Citations
634
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Recent Articles
1.
Aparicio A, Tidwell R, Yadav S, Chen J, Zhang M, Liu J, et al.
Clin Cancer Res
. 2024 Apr;
30(13):2751-2763.
PMID: 38683200
Purpose: To determine the efficacy and safety of risk-adapted combinations of androgen signaling inhibitors and inform disease classifiers for metastatic castration-resistant prostate cancers. Patients And Methods: In a modular, randomized...
2.
Yu Y, Chang K, Chen J, Bohlender R, Fowler J, Zhang D, et al.
HGG Adv
. 2022 Jan;
3(1):100078.
PMID: 35047863
Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a...
3.
Zheng J, Hoffman K, Chen J, Shivappa N, Sood A, Browman G, et al.
Br J Nutr
. 2020 Jun;
124(9):931-942.
PMID: 32475373
Diet has direct and indirect effects on health through inflammation and the gut microbiome. We investigated total dietary inflammatory potential via the literature-derived index (Dietary Inflammatory Index (DII®)) with gut...
4.
Hu F, Yu Y, Chen J, Hu H, Scheet P, Huff C
J Med Genet
. 2020 May;
58(3):145-153.
PMID: 32447321
Purpose: The contribution of rare genetic variation in the development of soft-tissue sarcoma (STS) remains underexplored. To address this gap, we conducted a whole-exome case-control and somatic-germline interaction study to...
5.
Chen J, Mitra A, Li S, Song S, Nguyen B, Chen J, et al.
Cancer Res
. 2020 Mar;
80(9):1819-1832.
PMID: 32127355
RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGFβ/SMAD signaling. SMAD3 and its adaptors, such as β2SP,...
6.
Hsieh C, Hung C, Lin C, Chen J, Chang K, Aithala S, et al.
Head Neck
. 2019 Jan;
41(6):1572-1582.
PMID: 30652371
Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in...
7.
Chen J, Hu F, Kugathasan S, Jorde L, Nix D, Rutherford A, et al.
G3 (Bethesda)
. 2018 Sep;
8(9):2881-2888.
PMID: 30166421
Crohn's disease is a complex genetic trait characterized by chronic relapsing intestinal inflammation. Genome wide association studies (GWAS) have identified more than 170 loci associated with the disease, accounting for...
8.
Yu Y, Hu H, Chen J, Hu F, Fowler J, Scheet P, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Jan;
1864(6 Pt B):2247-2254.
PMID: 29317335
While a number of genes have been implicated in melanoma susceptibility, the role of protein-coding variation in melanoma development and progression remains underexplored. To better characterize the role of germline...
9.
XPAT: a toolkit to conduct cross-platform association studies with heterogeneous sequencing datasets
Yu Y, Hu H, Bohlender R, Hu F, Chen J, Holt C, et al.
Nucleic Acids Res
. 2018 Jan;
46(6):e32.
PMID: 29294048
High-throughput sequencing data are increasingly being made available to the research community for secondary analyses, providing new opportunities for large-scale association studies. However, heterogeneity in target capture and sequencing technologies...
10.
Chen J, Zaidi S, Rao S, Chen J, Phan L, Farci P, et al.
Gastroenterology
. 2017 Sep;
154(1):195-210.
PMID: 28918914
Background & Aims: Development of hepatocellular carcinoma (HCC) is associated with alterations in the transforming growth factor-beta (TGF-β) signaling pathway, which regulates liver inflammation and can have tumor suppressor or...