Jiri Holoubek
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Explore the profile of Jiri Holoubek including associated specialties, affiliations and a list of published articles.
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7
Citations
15
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Recent Articles
1.
Berankova M, Holoubek J, Honig V, Matusova Z, Palus M, Salat J, et al.
J Neuroinflammation
. 2025 Jan;
22(1):22.
PMID: 39875898
Background: Tick-borne encephalitis (TBE) is the most common tick-borne viral infection in Eurasia. Outcomes range from asymptomatic infection to fatal encephalitis, with host genetics likely playing a role. BALB/c mice...
2.
Maryewski X, Krasilnikov M, Strakova P, Holoubek J, Frckova T, Panina I, et al.
ACS Appl Mater Interfaces
. 2025 Jan;
17(3):4502-4528.
PMID: 39772406
Enveloped viruses, such as flaviviruses and coronaviruses, are pathogens of significant medical concern that cause severe infections in humans. Some photosensitizers are known to possess virucidal activity against enveloped viruses,...
3.
Nagy G, Tombacz D, Prazsak I, Csabai Z, Dormo A, Gulyas G, et al.
mSphere
. 2024 Aug;
9(9):e0035624.
PMID: 39191390
In this study, we employed short- and long-read sequencing technologies to delineate the transcriptional architecture of the human monkeypox virus and to identify key regulatory elements that govern its gene...
4.
Holoubek J, Salat J, Kotoucek J, Kastl T, Vancova M, Huvarova I, et al.
Antiviral Res
. 2023 Dec;
221:105767.
PMID: 38040199
Tick-borne encephalitis virus (TBEV), the causative agent of tick-borne encephalitis (TBE), is a medically important flavivirus endemic to the European-Asian continent. Although more than 12,000 clinical cases are reported annually...
5.
Mikhnovets I, Holoubek J, Panina I, Kotoucek J, Gvozdev D, Chumakov S, et al.
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003673
Amphipathic perylene derivatives are broad-spectrum antivirals against enveloped viruses that act as fusion inhibitors in a light-dependent manner. The compounds target the lipid bilayer of the viral envelope using the...
6.
Strakova P, Bednar P, Kotoucek J, Holoubek J, Fortova A, Svoboda P, et al.
Virus Res
. 2023 Jun;
334:199158.
PMID: 37339718
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel broad-spectrum antivirals, including perylene-related compounds. In the present study,...
7.
Kakuk B, Dormo A, Csabai Z, Kemenesi G, Holoubek J, Ruzek D, et al.
Sci Data
. 2023 May;
10(1):262.
PMID: 37160911
The recent human Monkeypox outbreak underlined the importance of studying basic biology of orthopoxviruses. However, the transcriptome of its causative agent has not been investigated before neither with short-, nor...
8.
Holoubek J, Bednarova K, Haviernik J, Huvarova I, Dvorakova Z, cerny J, et al.
Nucleic Acids Res
. 2022 Apr;
50(8):4574-4600.
PMID: 35420134
We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human infections and numerous deaths every year. The...