Jiri Demuth
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Explore the profile of Jiri Demuth including associated specialties, affiliations and a list of published articles.
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21
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Recent Articles
1.
Bednarik S, Demuth J, Kernal J, Miletin M, Zimcik P, Novakova V
Inorg Chem
. 2024 Apr;
63(19):8799-8806.
PMID: 38679903
Phthalocyanines play fundamental roles as electron-acceptors in many different fields; thus, the study of structural features affecting electron-accepting properties of these macrocycles is highly desirable. A series of low-symmetry zinc(II)...
2.
Halaskova M, Kostelansky F, Demuth J, Hlbocanova I, Miletin M, Zimcik P, et al.
Chempluschem
. 2022 Jul;
87(9):e202200133.
PMID: 35880676
Effective interaction with biomembranes is essential for activity of photosensitizers; however, majority of them are highly charged symmetrical species. Amphiphilic cationic phthalocyanines differing in bulkiness of substitution on lipophilic part...
3.
Demuth J, Kantor M, Kucera R, Miletin M, Novakova V
Bioconjug Chem
. 2022 Apr;
33(5):788-794.
PMID: 35476400
Although triple labeling of molecular beacons has been documented to improve quenching efficiencies and studies generally assume similar benefits at long TaqMan probes, a limited number of works have studied...
4.
Demuth J, Gallego L, Kozlikova M, Machacek M, Kucera R, Torres T, et al.
J Med Chem
. 2021 Nov;
64(23):17436-17447.
PMID: 34813305
Because cancer is the second leading cause of death globally, investigation of new photosensitizers for photodynamic therapy is highly desirable. In this work, different peripherally substituted subphthalocyanines (SubPcs) with either...
5.
Cationic Versus Anionic Phthalocyanines for Photodynamic Therapy: What a Difference the Charge Makes
Kollar J, Machacek M, Halaskova M, Lenco J, Kucera R, Demuth J, et al.
J Med Chem
. 2020 Jul;
63(14):7616-7632.
PMID: 32618190
The literature reports on cationic and anionic phthalocyanines (Pcs) for photodynamic therapy suggest systematically significant differences in activity. In this work, ten different zinc(II) Pcs with carboxylate functions or quaternary...
6.
Demuth J, Miletin M, Machan M, Kantor M, Zimcik P, Novakova V
Chempluschem
. 2020 Mar;
85(3):527-537.
PMID: 32187858
Though tetrapyrazinoporphyrazines (TPyzPzs) are generally presented as universal dark quenchers for oligonucleotide probes, the availability of TPyzPzs bearing different functional groups suitable for attachment to 3', and 5' ends or...
7.
Karlikova M, cermakova V, Demuth J, Valer V, Miletin M, Novakova V, et al.
Dalton Trans
. 2019 Apr;
48(18):6162-6173.
PMID: 30938734
Magnesium(ii) tetrapyrazinoporphyrazines (TPyzPzs) are excellent red fluorophores (λF ∼ 663 nm, ΦF ∼ 0.53 in THF). In this work, a series of magnesium(ii) complexes of unsymmetrical TPyzPzs bearing one or...
8.
Demuth J, Kucera R, Kopecky K, Havlinova Z, Libra A, Novakova V, et al.
Chemistry
. 2018 Apr;
24(38):9658-9666.
PMID: 29683215
Unsymmetrical dialkylamino-substituted zinc azaphthalocyanine (AzaPc) exhibits unique spectral and photophysical properties for dark quenchers of fluorescence in DNA hybridization probes. The panchromatic light absorption of AzaPc from 300 nm up...
9.
Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers
Machacek M, Demuth J, cermak P, Vavreckova M, Hruba L, Jedlickova A, et al.
J Med Chem
. 2016 Sep;
59(20):9443-9456.
PMID: 27682881
Investigation of a series of tetra(3,4-pyrido)porphyrazines (TPyPzs) substituted with hydrophilic substituents revealed important structure-activity relationships for their use in photodynamic therapy (PDT). Among them, a cationic TPyPz derivative with total...
10.
Vachova L, Machacek M, Kucera R, Demuth J, cermak P, Kopecky K, et al.
Org Biomol Chem
. 2015 Apr;
13(20):5608-12.
PMID: 25881971
A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active...