Jimmy Z Liu
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Explore the profile of Jimmy Z Liu including associated specialties, affiliations and a list of published articles.
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34
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4938
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Recent Articles
1.
Tian R, Ge T, Kweon H, Rocha D, Lam M, Liu J, et al.
Nat Commun
. 2024 Feb;
15(1):1755.
PMID: 38409228
Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present...
2.
Chen C, Tian R, Ge T, Lam M, Sanchez-Andrade G, Singh T, et al.
Nat Genet
. 2023 May;
55(6):927-938.
PMID: 37231097
Compelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact cognitive function in the...
3.
Liu J, Chen C, Tsai E, Whelan C, Sexton D, John S, et al.
Nat Aging
. 2023 Apr;
2(4):289-294.
PMID: 37117740
Genetic predisposition has been shown to contribute substantially to the age at which we die. Genome-wide association studies (GWASs) have linked more than 20 loci to phenotypes related to human...
4.
Zimon M, Huang Y, Trasta A, Halavatyi A, Liu J, Chen C, et al.
Nat Commun
. 2021 Nov;
12(1):6411.
PMID: 34741066
Complex traits are characterized by multiple genes and variants acting simultaneously on a phenotype. However, studying the contribution of individual pairs of genes to complex traits has been challenging since...
5.
Schwartzentruber J, Cooper S, Liu J, Barrio-Hernandez I, Bello E, Kumasaka N, et al.
Nat Genet
. 2021 Feb;
53(4):585-586.
PMID: 33637963
No abstract available.
6.
Schwartzentruber J, Cooper S, Liu J, Barrio-Hernandez I, Bello E, Kumasaka N, et al.
Nat Genet
. 2021 Feb;
53(3):392-402.
PMID: 33589840
Genome-wide association studies have discovered numerous genomic loci associated with Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We performed an updated genome-wide AD meta-analysis, which...
7.
Baird D, Liu J, Zheng J, Sieberts S, Perumal T, Elsworth B, et al.
PLoS Genet
. 2021 Jan;
17(1):e1009224.
PMID: 33417599
Discovering drugs that efficiently treat brain diseases has been challenging. Genetic variants that modulate the expression of potential drug targets can be utilized to assess the efficacy of therapeutic interventions....
8.
Zheng J, Haberland V, Baird D, Walker V, Haycock P, Hurle M, et al.
Nat Genet
. 2020 Sep;
52(10):1122-1131.
PMID: 32895551
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein...
9.
Raghavan N, Dumitrescu L, Mormino E, Mahoney E, Lee A, Gao Y, et al.
JAMA Neurol
. 2020 Jun;
77(10):1288-1298.
PMID: 32568366
Importance: Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase...
10.
Darlay R, Ayers K, Mells G, Hall L, Liu J, Almarri M, et al.
PLoS Genet
. 2018 Dec;
14(12):e1007833.
PMID: 30507971
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional...