Jimena Perez-Lloret
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Explore the profile of Jimena Perez-Lloret including associated specialties, affiliations and a list of published articles.
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11
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219
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Recent Articles
1.
Bailey C, Sanderson T, Townsley H, Goldman J, Black J, Young G, et al.
Lancet
. 2023 Jun;
402(10395):21-24.
PMID: 37348521
No abstract available.
2.
Virdi G, Choi M, Evans J, Yao Z, Athauda D, Strohbuecker S, et al.
NPJ Parkinsons Dis
. 2022 Nov;
8(1):162.
PMID: 36424392
Mutations in the SNCA gene cause autosomal dominant Parkinson's disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that...
3.
Borel V, Boeing S, van Wietmarschen N, Sridharan S, Hill B, Ombrato L, et al.
Cell Rep
. 2022 Jun;
39(9):110871.
PMID: 35649380
The maintenance of genome stability relies on coordinated control of origin activation and replication fork progression. How the interplay between these processes influences human genetic disease and cancer remains incompletely...
4.
Anjos-Afonso F, Buettner F, Mian S, Rhys H, Perez-Lloret J, Garcia-Albornoz M, et al.
Nat Commun
. 2022 Apr;
13(1):2048.
PMID: 35440586
The heterogeneous nature of human CD34 hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including...
5.
Entwistle L, Pelly V, Coomes S, Kannan Y, Perez-Lloret J, Czieso S, et al.
Cell Host Microbe
. 2017 Oct;
22(4):484-493.e5.
PMID: 29024642
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A group 1B (PLAg1B) as...
6.
Kannan Y, Entwistle L, Pelly V, Perez-Lloret J, Walker A, Ley S, et al.
PLoS Pathog
. 2017 Aug;
13(7):e1006536.
PMID: 28759611
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens....
7.
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
Pelly V, Coomes S, Kannan Y, Gialitakis M, Entwistle L, Perez-Lloret J, et al.
J Exp Med
. 2017 May;
214(6):1809-1826.
PMID: 28507062
Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4Foxp3 regulatory T cells (T reg cells) impedes protective responses,...
8.
Kannan Y, Perez-Lloret J, Li Y, Entwistle L, Khoury H, Papoutsopoulou S, et al.
PLoS Pathog
. 2016 Aug;
12(8):e1005783.
PMID: 27487182
Persistent TH2 cytokine responses following chronic helminth infections can often lead to the development of tissue pathology and fibrotic scarring. Despite a good understanding of the cellular mechanisms involved in...
9.
Perez-Lloret J, Okoye I, Guidi R, Kannan Y, Coomes S, Czieso S, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(5):E568-76.
PMID: 26787865
There is a paucity of new therapeutic targets to control allergic reactions and forestall the rising trend of allergic diseases. Although a variety of immune cells contribute to allergy, cytokine-secreting...
10.
Coomes S, Pelly V, Kannan Y, Okoye I, Czieso S, Entwistle L, et al.
PLoS Pathog
. 2015 Jul;
11(7):e1004994.
PMID: 26147567
Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the chronicity of...