Jim Koh
Overview
Explore the profile of Jim Koh including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
66
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Recent Articles
1.
Tyler E, Gutierrez Del Arroyo A, Hughes B, Wallis R, Garbe J, Stampfer M, et al.
Aging Cell
. 2021 Feb;
20(3):e13318.
PMID: 33547862
Senescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases in vivo. Although the INK4/ARF locus is known to be essential for senescence programmes,...
2.
Bishop C, Bergin A, Fessart D, Borgdorff V, Hatzimasoura E, Garbe J, et al.
Mol Cell
. 2010 Nov;
40(4):533-47.
PMID: 21095584
In a genome-wide siRNA analysis of p16(INK4a) (p16) modulators, we identify the Hedgehog (Hh) pathway component SUFU and formally demonstrate that Hh signaling promotes mitogenesis by suppression of p16. A...
3.
Paya A, Alenda C, Perez-Carbonell L, Rojas E, Soto J, Guillen C, et al.
Clin Cancer Res
. 2009 Apr;
15(9):3156-62.
PMID: 19383812
Purpose: Immunohistochemistry for mismatch repair proteins has shown utility in the identification of Lynch syndrome, but majority of tumors with loss of MLH1 expression are due to sporadic hypermethylation of...
4.
Furth E, Gustafson K, Dai C, Gibson S, Menard-Katcher P, Chen T, et al.
Neoplasia
. 2006 Jul;
8(6):429-36.
PMID: 16820088
p16(INK4a) is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative...