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Jie Ping

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Articles 141
Citations 3184
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Recent Articles
1.
Ping J, Liu X, Lu Y, Quan C, Fan P, Lu H, et al.
Cell Genom . 2025 Mar; 5(3):100782. PMID: 40043709
To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han...
2.
Chen W, Song X, Wu J, Zhong Y, Edjah P, Zhang Q, et al.
J Nat Prod . 2025 Jan; 88(2):336-348. PMID: 39874532
In the search for novel natural products with hepatoprotective effects against acetaminophen-induced acute liver injury, the marine-derived fungus WHUF0198 was investigated. Seventeen undescribed pyranopyridone alkaloids, aculeapyridones A-Q (-), were isolated...
3.
Jia G, Chen Z, Ping J, Cai Q, Tao R, Li C, et al.
Nat Genet . 2025 Jan; 57(1):80-87. PMID: 39753771
Genome-wide association studies have identified approximately 200 genetic risk loci for breast cancer, but the causal variants and target genes are mostly unknown. We sought to fine-map all known breast...
4.
Zhang M, Li K, Huang X, Xu D, Zong R, Hu Q, et al.
JHEP Rep . 2024 Dec; 7(1):101242. PMID: 39717502
Background & Aims: Hepatic immune imbalance is crucial for driving metabolic dysfunction-associated steatotic liver disease (MASLD) progression. However, the role of hepatic regulatory T cells (Tregs) in MASLD initiation and...
5.
He J, Perera D, Wen W, Ping J, Li Q, Lyu L, et al.
Nucleic Acids Res . 2024 Nov; 53(1). PMID: 39535029
Transcriptome-wide association studies (TWAS) have been successful in identifying disease susceptibility genes by integrating cis-variants predicted gene expression with genome-wide association studies (GWAS) data. However, trans-variants for predicting gene expression...
6.
Zhao T, Xu S, Ping J, Jia G, Dou Y, Henry J, et al.
Br J Cancer . 2024 Oct; 131(11):1796-1804. PMID: 39468330
Background: Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final...
7.
Zong R, Zheng Y, Yan Y, Sun W, Kong L, Huang Y, et al.
Hepatol Int . 2024 Aug; 18(6):1781-1791. PMID: 39138757
Background & Aims: Despite increasing knowledge regarding the cellular and molecular mechanisms of liver fibrogenesis, there is currently no approved drug for the treatment of liver fibrosis. Mesenchymal stem cells...
8.
Morimoto M, Ryu E, Steger B, Dixit A, Saito Y, Yoo J, et al.
Am J Hum Genet . 2024 Aug; 111(9):1970-1993. PMID: 39106866
The precise regulation of DNA replication is vital for cellular division and genomic integrity. Central to this process is the replication factor C (RFC) complex, encompassing five subunits, which loads...
9.
Yang Y, Chen Y, Xu S, Guo X, Jia G, Ping J, et al.
Nat Commun . 2024 Jul; 15(1):6071. PMID: 39025880
The relationship between tissue-specific DNA methylation and cancer risk remains inadequately elucidated. Leveraging resources from the Genotype-Tissue Expression consortium, here we develop genetic models to predict DNA methylation at CpG...
10.
Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, et al.
medRxiv . 2024 Jun; PMID: 38853880
Identifying risk protein targets and their therapeutic drugs is crucial for effective cancer prevention. Here, we conduct integrative and fine-mapping analyses of large genome-wide association studies data for breast, colorectal,...