Jianhan Chen
Overview
Explore the profile of Jianhan Chen including associated specialties, affiliations and a list of published articles.
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Articles
110
Citations
2008
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Recent Articles
1.
Jia Z, Zhang G, Shi J, Cui J, Chen J
bioRxiv
. 2025 Jan;
PMID: 39868145
The big potassium (BK) channels remain open with a small limiting probability of ~ 10 at minimal Ca and negative voltages < -100 mV. The molecular origin and functional significance...
2.
Tama F, Chen J
Biophys Rev
. 2024 Dec;
16(5):529-531.
PMID: 39618800
The session "Data Science for Integrated Dynamic Structural Biology" was a notable success at the joint congress of the 21st IUPAB and the 62nd BSJ (Biophysics Society of Japan). This...
3.
Li S, Chen J
bioRxiv
. 2024 Nov;
PMID: 39605385
RNAs are major drivers of phase separation in the formation of biomolecular condensates, and can undergo protein-free phase separation in the presence of divalent ions or crowding agents. Much remains...
4.
Shorkey S, Zhang Y, Sharp J, Clingman S, Nguyen L, Chen J, et al.
Biophys J
. 2024 Nov;
124(1):145-157.
PMID: 39578408
The flaviviral NS2B/NS3 protease is a conserved enzyme required for flavivirus replication. Its highly dynamic conformation poses major challenges but also offers opportunities for antiviral inhibition. Here, we established a...
5.
Gong X, Zhang Y, Chen J
J Phys Chem B
. 2024 Nov;
128(47):11554-11564.
PMID: 39536029
Recent years have witnessed drastic improvements in general-purpose explicit solvent protein force fields, partially driven by the need to study intrinsically disordered proteins (IDPs), and yet the state-of-the-art force fields...
6.
Chen J, Huang Y, Li R, Wu H, Ke J, Liu C, et al.
Comput Methods Biomech Biomed Engin
. 2024 Oct;
:1-11.
PMID: 39363573
Aiming to simplify the data acquisition process for balance diagnosis and focused on muscle, a direct factor affecting balance, to assess and judge postural stability. Utilizing a publicly available kinematic...
7.
Nordquist E, Jia Z, Chen J
J Chem Inf Model
. 2024 Sep;
64(19):7616-7625.
PMID: 39264311
The Ca and voltage-gated big potassium (BK) channels are implicated in various diseases, including heart disease, asthma, epilepsy, and cancer, but remain an elusive drug target. A class of negatively...
8.
Le S, Krishna J, Gupta P, Dutta R, Li S, Chen J, et al.
Biomacromolecules
. 2024 Sep;
25(10):6229-6249.
PMID: 39254158
Protein-protein interactions (PPIs) are central to the cellular signaling and regulatory networks that underlie many physiological and pathophysiological processes. It is challenging to target PPIs using traditional small molecule or...
9.
Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, et al.
Nat Commun
. 2024 Jun;
15(1):5216.
PMID: 38890331
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion...
10.
Shorkey S, Zhang Y, Sharp J, Clingman S, Nguyen L, Chen J, et al.
bioRxiv
. 2024 May;
PMID: 38798384
The flaviviral NS2B/NS3 protease is a conserved enzyme required for flavivirus replication. Its highly dynamic conformation poses major challenges but also offers opportunities for antiviral inhibition. Here, we established a...