Jiafu Long
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Explore the profile of Jiafu Long including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Mo Q, Liu B, Liu C, Long J, Zhou H
Biochem Biophys Res Commun
. 2024 Dec;
745:151238.
PMID: 39732119
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes play critical roles in regulating gene expression and DNA accessibility, and more than 20 % of cancers have mutations in genes encoding chromatin...
2.
Yang J, Dan J, Zhao N, Liu L, Wang H, Liu Q, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2407490121.
PMID: 39705314
Zygotic genome activation occurs in two-cell (2C) embryos, and a 2C-like state is also activated in sporadic (~1%) naïve embryonic stem cells in mice. Elevated chromatin accessibility is critical for...
3.
Song N, Song Y, Hu B, Liu X, Yu X, Zhou H, et al.
Adv Healthc Mater
. 2022 Nov;
12(5):e2202039.
PMID: 36353887
Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe. Herein, a proof-of-concept strategy is...
4.
Chen F, Liu B, Zhou H, Long J
Proc Natl Acad Sci U S A
. 2022 Sep;
119(40):e2207332119.
PMID: 36161924
Rpb1, the largest subunit of RNA polymerase II (RNAPII), is rapidly polyubiquitinated and degraded in response to DNA damage; this process is considered to be a "mechanism of last resort''...
5.
Huang F, Qu A, Yang H, Zhu L, Zhou H, Liu J, et al.
ACS Macro Lett
. 2022 Jun;
7(8):983-989.
PMID: 35650950
Amyloid β peptide (Aβ) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Currently, decreasing Aβ production and preventing Aβ aggregation are thought to be important strategies in...
6.
Liu X, Li M, Liu J, Song Y, Hu B, Wu C, et al.
J Am Chem Soc
. 2022 May;
144(21):9312-9323.
PMID: 35587998
Self-sorting is a common phenomenon in eukaryotic cells and represents one of the versatile strategies for the formation of advanced functional materials; however, developing artificial self-sorting assemblies within living cells...
7.
Cheng Y, Shen Z, Gao Y, Chen F, Xu H, Mo Q, et al.
Nat Commun
. 2022 May;
13(1):2724.
PMID: 35585082
Oncoprotein SS18-SSX is a hallmark of synovial sarcomas. However, as a part of the SS18-SSX fusion protein, SS18's function remains unclear. Here, we depict the structures of both human SS18/BRG1...
8.
Song Y, Li M, Song N, Liu X, Wu G, Zhou H, et al.
J Am Chem Soc
. 2022 Apr;
144(15):6907-6917.
PMID: 35388694
Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy in the creation of theranostic agents, which, however, is limited by the strong dependence on enzyme overexpression. Herein, we reported...
9.
Chen F, Liu B, Zeng J, Guo L, Ge X, Feng W, et al.
J Mol Biol
. 2021 Dec;
434(2):167369.
PMID: 34852272
The highly conserved multifunctional polymerase-associated factor 1 (Paf1) complex (PAF1C), which consists of five core subunits: Ctr9, Paf1, Leo1, Cdc73, and Rtf1, acts as a diverse hub that regulates all...
10.
Chen F, Liu B, Guo L, Ge X, Feng W, Li D, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34385316
The highly conserved multifunctional polymerase-associated factor 1 (Paf1) complex (PAF1C), composed of five core subunits Paf1, Leo1, Ctr9, Cdc73, and Rtf1, participates in all stages of transcription and is required...