Jessica D Rosarda
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Explore the profile of Jessica D Rosarda including associated specialties, affiliations and a list of published articles.
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13
Citations
100
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Recent Articles
1.
Kline G, Madrazo N, Cole C, Pannikkat M, Bollong M, Rosarda J, et al.
RSC Chem Biol
. 2024 Aug;
5(9):866-876.
PMID: 39211477
We previously showed that the proteostasis regulator compound AA147 (-(2-hydroxy-5-methylphenyl)benzenepropanamide) potently protects against neurotoxic insults, such as glutamate-induced oxytosis. Though AA147 is a selective activator of the ATF6 arm of...
2.
Armstrong R, Sullivan G, Perl D, Rosarda J, Radomski K
Trends Neurosci
. 2024 Aug;
47(9):677-692.
PMID: 39127568
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with...
3.
Madrazo N, Khattar Z, Powers E, Rosarda J, Wiseman R
Mol Biol Cell
. 2024 Mar;
35(5):ar74.
PMID: 38536439
Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial dysfunction implicated in etiologically diverse diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria in...
4.
Madrazo N, Khattar Z, Powers E, Rosarda J, Wiseman R
bioRxiv
. 2024 Feb;
PMID: 38352575
Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial dysfunction implicated in etiologically-diverse diseases. This has led to considerable interest in defining the biological mechanisms responsible for regulating mitochondria in...
5.
Stanton C, Sun J, Nutsch K, Rosarda J, Nguyen T, Li-Ma C, et al.
ACS Chem Biol
. 2024 Jan;
19(2):254-265.
PMID: 38198472
The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines, including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory...
6.
Perea V, Baron K, Dolina V, Aviles G, Kim G, Rosarda J, et al.
Cell Chem Biol
. 2023 Nov;
30(12):1571-1584.e5.
PMID: 37922906
The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead...
7.
Rosarda J, Giles S, Harkins-Perry S, Mills E, Friedlander M, Wiseman R, et al.
Nat Commun
. 2023 Jul;
14(1):4119.
PMID: 37433773
The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce...
8.
Stanton C, Sun J, Nutsch K, Rosarda J, Nguyen T, Li-Ma C, et al.
bioRxiv
. 2023 Jul;
PMID: 37398499
The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory...
9.
Perea V, Baron K, Dolina V, Aviles G, Rosarda J, Guo X, et al.
bioRxiv
. 2023 Mar;
PMID: 36945406
The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead...
10.
Rosarda J, Baron K, Nutsch K, Kline G, Stanton C, Kelly J, et al.
ACS Chem Biol
. 2021 Nov;
16(12):2852-2863.
PMID: 34797633
The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer's disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidative...